General Information:

Id: 11,758 (click here to show other Interactions for entry)
Diseases: Pulmonary fibrosis, idiopathic - [OMIM]
Homo sapiens
article
Reference: Shao M et al.(2019) Exogenous angiotensin (1-7) directly inhibits epithelial-mesenchymal transformation induced by transforming growth factor-beta1 in alveolar epithelial cells Biomed. Pharmacother. 117 [PMID: 31387171]

Interaction Information:

Comment Exogenous Ang-(1-7) suppresses the TGF-beta1-induced epithelial-mesenchymal transition in A549 cells.
Formal Description
Interaction-ID: 116447

gene/protein

Angiotensin (1-7)

decreases_activity of

in A549 cells
Comment Ang-(1-7) inhibits TGF-beta1-induced phosphorylation of Smad2 and Smad3, and suppressed the expression of the downstream target gene of TGF-beta1-SMAD signaling, including ZEB1, ZEB2, TWIST, and SNAIL1.
Formal Description
Interaction-ID: 116450

gene/protein

Angiotensin (1-7)

decreases_activity of

gene/protein

TGFB1

in A549 cells
Drugbank entries Show/Hide entries for TGFB1
Comment Ang-(1-7) inhibits TGF-beta1-induced phosphorylation of Smad2 and Smad3, and suppressed the expression of the downstream target gene of TGF-beta1-SMAD signaling, including ZEB1, ZEB2, TWIST, and SNAIL1.
Formal Description
Interaction-ID: 116452

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

ZEB1

in A549 cells; via inhibition of TGFbeta1-SMAD signaling
Comment Ang-(1-7) inhibits TGF-beta1-induced phosphorylation of Smad2 and Smad3, and suppressed the expression of the downstream target gene of TGF-beta1-SMAD signaling, including ZEB1, ZEB2, TWIST, and SNAIL1.
Formal Description
Interaction-ID: 116453

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

ZEB2

in A549 cells; via inhibition of TGFbeta1-SMAD signaling
Comment Ang-(1-7) inhibits TGF-beta1-induced phosphorylation of Smad2 and Smad3, and suppressed the expression of the downstream target gene of TGF-beta1-SMAD signaling, including ZEB1, ZEB2, TWIST, and SNAIL1.
Formal Description
Interaction-ID: 116454

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

TWIST1

in A549 cells; via inhibition of TGFbeta1-SMAD signaling
Comment Ang-(1-7) inhibits TGF-beta1-induced phosphorylation of Smad2 and Smad3, and suppressed the expression of the downstream target gene of TGF-beta1-SMAD signaling, including ZEB1, ZEB2, TWIST, and SNAIL1.
Formal Description
Interaction-ID: 116455

gene/protein

Angiotensin (1-7)

decreases_expression of

gene/protein

SNAI1

in A549 cells; via inhibition of TGFbeta1-SMAD signaling
Comment Phosphorylation of mTOR induced by TGF-beta1 is suppressed by Ang-(1-7) treatment in A549 cells.
Formal Description
Interaction-ID: 116456

gene/protein

Angiotensin (1-7)

affects_activity of

gene/protein

MTOR

in A549 cells; via inhibition of TGFbeta1-SMAD signaling
Drugbank entries Show/Hide entries for MTOR