General Information:

Id: 11,756 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
review
Reference: Sriram K and Insel PAA hypothesis for pathobiology and treatment of COVID-19: the centrality of ACE1/ACE2 imbalance [PMID: 32333398]

Interaction Information:

Comment ACE2 knockout mice had dramatically increased lung injury, effects that were reduced by treating with recombinant human ACE2. Conversely, ACE-deficient mice had reduced severity of injury, supporting the concept that ACE1/ACE2 balance is a central mediator of lung injury.
Formal Description
Interaction-ID: 116635

gene/protein

ACE2

decreases_activity of

phenotype

lung injury

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