General Information:

Id: 11,756 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
review
Reference: Sriram K and Insel PAA hypothesis for pathobiology and treatment of COVID-19: the centrality of ACE1/ACE2 imbalance [PMID: 32333398]

Interaction Information:

Comment In addition to pulmonary injury, COVID-19 can cause cardiac complications, most notable is myocarditis, perhaps facilitated by ACE2 expression on cardiac myocytes.
Formal Description
Interaction-ID: 116443

gene/protein

ACE2

is_expressed_in

tissue/cell line

cardiac muscle fiber

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Comment ACE2 is highly expressed in the lung parenchyma, particularly in type II pneumocytes (type II alveolar cells).
Formal Description
Interaction-ID: 116444

gene/protein

ACE2

is_expressed_in

tissue/cell line

alveolar cell type II

Drugbank entries Show/Hide entries for ACE2
Comment ACE2 knockout mice had dramatically increased lung injury, effects that were reduced by treating with recombinant human ACE2. Conversely, ACE-deficient mice had reduced severity of injury, supporting the concept that ACE1/ACE2 balance is a central mediator of lung injury.
Formal Description
Interaction-ID: 116635

gene/protein

ACE2

decreases_activity of

phenotype

lung injury

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