General Information:

Id: 11,756 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
Reference: Sriram K and Insel PAA hypothesis for pathobiology and treatment of COVID-19: the centrality of ACE1/ACE2 imbalance [PMID: 32333398]

Interaction Information:

Comment ANG II promotes a range of pro-apoptotic, inflammatory, fibrotic and edema-associated processes in the alveolar microenvironment. The epithelium becomes compromised, paving the way for secondary infection (e.g., bacterial pneumonia). As a result, immune response is further enhanced. On the opposite, ACE2 and ANG (1-7) reduce pulmonary injury.
Formal Description
Interaction-ID: 116634


Angiotensin (1-7)

decreases_activity of

in the alveolar microenvironment