General Information:

Id: 11,748 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
Reference: Sriram K and Insel PA(2020) A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance Br J Pharmacol 177: 4825-4844 [PMID: 32333398]

Interaction Information:

Comment Infection of cells by SARS viruses that bind ACE2 results in two effects: inhibition of ACE2 activity and decrease of ACE2 expression in infected cells. A decrease in ACE activity creates an imbalance in signaling by ACE1 and ACE2 products.
Formal Description
Interaction-ID: 116406


SARS virus

decreases_activity of



by binding to ACE2
Drugbank entries Show/Hide entries for ACE2