General Information:

Id: 11,748 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
review
Reference: Sriram K and Insel PA(2020) A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance Br J Pharmacol 177: 4825-4844 [PMID: 32333398]

Interaction Information:

Comment Compared to SARS-COV-1, SARS-CoV-2 has about 4-fold higher affinity for ACE2.
Formal Description
Interaction-ID: 116293

environment

SARS-CoV-2

interacts (colocalizes) with

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2
Comment Renin cleaves AGT to form Angiotensin 1 (ANG 1), which in turn generates ANG II or ANG 1-9, primarily from the actions of ACE1 and ACE2, respectively.
Formal Description
Interaction-ID: 116365

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-9)

Drugbank entries Show/Hide entries for ACE2
Comment Renin cleaves AGT to form Angiotensin 1 (ANG 1), which in turn generates ANG II or ANG 1-9, primarily from the actions of ACE1 and ACE2, respectively.
Formal Description
Interaction-ID: 116366

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin I

Drugbank entries Show/Hide entries for ACE2
Comment ANG II is cleaved by multiple enzymes, e.g. prolyl endopeptidase (PREP), but most importantly ACE2, to form ANG (1-7). ANG II also forms ANG IV via the action of aminopeptidases.
Formal Description
Interaction-ID: 116369

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for ACE2
Comment ANG II is cleaved by multiple enzymes, e.g. prolyl endopeptidase (PREP), but most importantly ACE2, to form ANG (1-7). ANG II also forms ANG IV via the action of aminopeptidases.
Formal Description
Interaction-ID: 116370

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin II

Drugbank entries Show/Hide entries for ACE2
Comment ACE2, in particular its catalytic ectodomain, can be shed from cells into the circulation as soluble ACE2, an action mediated by the metalloprotease ADAM17, an activator of Notch pathway.
Formal Description
Interaction-ID: 116388

gene/protein

ADAM17

affects_activity of

gene/protein

ACE2

via proteolysis
Drugbank entries Show/Hide entries for ADAM17 or ACE2
Comment Infection of cells by SARS viruses that bind ACE2 results in two effects: inhibition of ACE2 activity and decrease of ACE2 expression in infected cells. A decrease in ACE activity creates an imbalance in signaling by ACE1 and ACE2 products.
Formal Description
Interaction-ID: 116406

environment

SARS virus

decreases_activity of

gene/protein

ACE2

by binding to ACE2
Drugbank entries Show/Hide entries for ACE2
Comment Infection of cells by SARS viruses that bind ACE2 results in two effects: inhibition of ACE2 activity and decrease of ACE2 expression in infected cells. A decrease in ACE activity creates an imbalance in signaling by ACE1 and ACE2 products.
Formal Description
Interaction-ID: 116440

environment

SARS virus

decreases_expression of

gene/protein

ACE2

Drugbank entries Show/Hide entries for ACE2