General Information:

Id: 11,748 (click here to show other Interactions for entry)
Diseases: COVID-19
Homo sapiens
review
Reference: Sriram K and Insel PA(2020) A hypothesis for pathobiology and treatment of COVID-19: The centrality of ACE1/ACE2 imbalance Br J Pharmacol 177: 4825-4844 [PMID: 32333398]

Interaction Information:

Comment ANG II is cleaved by multiple enzymes, most importantly ACE2, to form ANG (1-7). ANG II also forms ANG IV via the action of aminopeptidases.
Formal Description
Interaction-ID: 116367

gene/protein

Angiotensin II

increases_quantity of

gene/protein

Angiotensin (1-7)

via cleavage by ACE2 and other enzymes
Comment ANG II is cleaved by multiple enzymes, e.g. prolyl endopeptidase (PREP), but most importantly ACE2, to form ANG (1-7). ANG II also forms ANG IV via the action of aminopeptidases.
Formal Description
Interaction-ID: 116369

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for ACE2
Comment ANG (1-7) acts primarily via the G protein-coupled receptor MAS1, and forms ANG (1-5), which signals via MRGPRD. ANG (1-7) can also act via the AGTR2 receptor but with much lower affinity than ANG II.
Formal Description
Interaction-ID: 116373

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

MAS1

Comment ANG (1-7) acts primarily via the G protein-coupled receptor MAS1, and forms ANG (1-5), which signals via MRGPRD. ANG (1-7) can also act via the AGTR2 receptor but with much lower affinity than ANG II.
Formal Description
Interaction-ID: 116375

gene/protein

Angiotensin (1-7)

increases_quantity of

gene/protein

Angiotensin (1-5)

Comment ANG (1-7) acts primarily via the G protein-coupled receptor MAS1, and forms ANG (1-5), which signals via MRGPRD. ANG (1-7) can also act via the AGTR2 receptor but with much lower affinity than ANG II.
Formal Description
Interaction-ID: 116378

gene/protein

Angiotensin (1-7)

increases_activity of

gene/protein

AGTR2

but with lower affinity than ANG II
Drugbank entries Show/Hide entries for AGTR2
Comment ANG II is cleaved by multiple enzymes, e.g. prolyl endopeptidase (PREP), but most importantly ACE2, to form ANG (1-7). ANG II also forms ANG IV via the action of aminopeptidases.
Formal Description
Interaction-ID: 116398

gene/protein

PREP

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for PREP