General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment Obese animals usually showincreased expression of the systemic renin-angiotensin system (RAS)components and show high expression of local RAS elements such asangiotensin-converting enzyme (ACE) and Angiotensin II type I re-ceptor (AT1R) in the pancrea.
Formal Description
Interaction-ID: 116173

disease

Obesity

increases_expression of

gene/protein

ACE

in pancreas
Drugbank entries Show/Hide entries for ACE
Comment ACE is responsible for the conversion of angiotensin 1 into angiotensin 2 and is mainly expressed in the islet periphery and in its microvasculature.
Formal Description
Interaction-ID: 116319

gene/protein

ACE

decreases_quantity of

gene/protein

Angiotensin I

Drugbank entries Show/Hide entries for ACE
Comment ACE is responsible for the conversion of angiotensin 1 into angiotensin 2 and is mainly expressed in the islet periphery and in its microvasculature.
Formal Description
Interaction-ID: 116323

gene/protein

ACE

increases_quantity of

gene/protein

Angiotensin II

Drugbank entries Show/Hide entries for ACE
Comment Osteoprotegerin (OPG) is a protein that is homologous to the tumor necrosis factor (TNF) receptors and favors the increase in monocyte/macrophage infiltration, fibrosis and apoptosis that reduces islet function in diabetic mice. OPG induces a significant increase in the ACE and AT1R gene and protein expression, and the molecular mechanism maybe linked to activation of the mitogen-activated protein kinase (MAPK) and NF-kappaB transduction pathways.
Formal Description
Interaction-ID: 116432

gene/protein

TNFRSF11B

increases_expression of

gene/protein

ACE

Drugbank entries Show/Hide entries for ACE