General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment The angiotensin 2 (ANG2) receptors are found within the islet, and AT1R is mainly found in the islet core where the beta cells responsible for insulin secretion are located. The angiotensin II type 2 receptor (AT2R) is found in nearby delta cells that secrete somatostatin. Angiotensin-convertingenzyme 2 (ACE2) is expressed by alpha cells and the islet micro-vasculature, though the latter is more implicated in glycemic homeostasis and islet maintenance.
Formal Description
Interaction-ID: 116331

gene/protein

ACE2

is_expressed_in

tissue/cell line

pancreatic islet

Drugbank entries Show/Hide entries for ACE2
Comment The ACE2/MAS receptor axis converts angiotensin 2 (ANG2) to ANG1-7 and counters the harmful effects caused by the interaction of ANG2 with the AT1R.
Formal Description
Interaction-ID: 116346

gene/protein

ACE2

decreases_quantity of

gene/protein

Angiotensin II

Drugbank entries Show/Hide entries for ACE2
Comment The ACE2/MAS receptor axis converts angiotensin 2 (ANG2) to ANG1-7 and counters the harmful effects caused by the interaction of ANG2 with the AT1R.
Formal Description
Interaction-ID: 116348

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-7)

Drugbank entries Show/Hide entries for ACE2
Comment There is increased islet vascularization observed in obese subjects, and this could be a compensatory response to support the augmented beta cell mass due to islet hypertrophy. If ACE2 deletion occurs, then the vascular compensation in the islets is reduced.
Formal Description
Interaction-ID: 116381

gene/protein

ACE2

affects_activity of

phenotype

increased pancreatic islet vascularization

Drugbank entries Show/Hide entries for ACE2
Comment Reduced ACE2 expression in islet endothelial cells rather than in islet cells themselves leads to a decreased tolerance to glucose and impaired GSIS.
Formal Description
Interaction-ID: 116382
Drugbank entries Show/Hide entries for ACE2
Comment The reduction or impairment of ACE2 functioning, which is responsible for cleaving ANG2 to ANG (1-7), contributes to islet dysfunction and to T2DM due to impaired beta cell proliferation and the resulting reduced beta cell mass.
Formal Description
Interaction-ID: 116389

gene/protein

ACE2

affects_activity of

Drugbank entries Show/Hide entries for ACE2
Comment The reduction or impairment of ACE2 functioning, which is responsible for cleaving ANG2 to ANG (1-7), contributes to islet dysfunction and to T2DM due to impaired beta cell proliferation and the resulting reduced beta cell mass.
Formal Description
Interaction-ID: 116390

gene/protein

ACE2

affects_activity of

Drugbank entries Show/Hide entries for ACE2
Comment Decreased ACE2 expression and activity stimulate a compensatory increase in AT1R expression and result in enhanced oxidative stress in the pancreas.
Formal Description
Interaction-ID: 116395

gene/protein

ACE2

affects_expression of

gene/protein

AGTR1

in pancreas
Drugbank entries Show/Hide entries for ACE2 or AGTR1
Comment Decreased ACE2 expression and activity stimulate a compensatory increase in AT1R expression and result in enhanced oxidative stress in the pancreas.
Formal Description
Interaction-ID: 116396

gene/protein

ACE2

affects_activity of

in pancreas
Drugbank entries Show/Hide entries for ACE2
Comment Patients with pre-diabetes and diabetes benefited from ACE inhibition and showed reduced islet inflammation and an improved ACE2 axis.
Formal Description
Interaction-ID: 116407

drug/chemical compound

ACE inhibitor

increases_activity of

gene/protein

ACE2

in pancreatic islets
Drugbank entries Show/Hide entries for ACE2
Comment Mitochondrial metabolism plays an important role in the release of insulin and glucose homeostasis. Evidence shows that overexpression of ACE2 can regulate mitochondrial function in pancreatic beta cells and restore GSIS.
Formal Description
Interaction-ID: 116408

gene/protein

ACE2

increases_activity of

cellular component

mitochondrion

in pancreatic beta cells
Drugbank entries Show/Hide entries for ACE2