General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment The reduction or impairment of ACE2 functioning, which is responsible for cleaving ANG2 to ANG (1-7), contributes to islet dysfunction and to T2DM due to impaired beta cell proliferation and the resulting reduced beta cell mass.
Formal Description
Interaction-ID: 116389



affects_activity of

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