General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment There is increased islet vascularization observed in obese subjects, and this could be a compensatory response to support the augmented beta cell mass due to islet hypertrophy. If ACE2 deletion occurs, then the vascular compensation in the islets is reduced.
Formal Description
Interaction-ID: 116381

gene/protein

ACE2

affects_activity of

phenotype

increased pancreatic islet vascularization

Drugbank entries Show/Hide entries for ACE2