General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment ANG1-7 has an important role in the regulation of insulin secretion in mouse islets both in vitro and in vivo by controlling MAS receptor-dependent signaling. The effects of the ANG1-7-dependent MAS receptor are not linked to insulin excitation-secretion coupling alterations. However, the intracellular increase in cAMP modulates the accessory pathway promoting an improvement in insulin secretion.
Formal Description
Interaction-ID: 116377

gene/protein

Angiotensin (1-7)

increases_quantity of

drug/chemical compound

cAMP

in the cell
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