General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mammalia
review
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment The ACE2/MAS receptor axis converts angiotensin 2 (ANG2) to ANG1-7 and counters the harmful effects caused by the interaction of ANG2 with the AT1R.
Formal Description
Interaction-ID: 116348

gene/protein

ACE2

increases_quantity of

gene/protein

Angiotensin (1-7)

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Comment ANG1-7 has an important role in the regulation of insulin secretion in mouse islets both in vitro and in vivo by controlling MAS receptor-dependent signaling.
Formal Description
Interaction-ID: 116350

gene/protein

Angiotensin (1-7)

affects_activity of

Comment ANG1-7 has an important role in the regulation of insulin secretion in mouse islets both in vitro and in vivo by controlling MAS receptor-dependent signaling.
Formal Description
Interaction-ID: 116374

gene/protein

Angiotensin (1-7)

affects_activity of

gene/protein

MAS1

Comment ANG1-7 has an important role in the regulation of insulin secretion in mouse islets both in vitro and in vivo by controlling MAS receptor-dependent signaling. The effects of the ANG1-7-dependent MAS receptor are not linked to insulin excitation-secretion coupling alterations. However, the intracellular increase in cAMP modulates the accessory pathway promoting an improvement in insulin secretion.
Formal Description
Interaction-ID: 116377

gene/protein

Angiotensin (1-7)

increases_quantity of

drug/chemical compound

cAMP

in the cell
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Comment Oxidative stress is pivotal for beta cell loss. ANG (1-7) treatment reduced ROS generation by improving mitochondrial function ina n in vitro model of oxidative stress using INS-1 cells.
Formal Description
Interaction-ID: 116434

gene/protein

Angiotensin (1-7)

decreases_activity of

Comment Neprilysin is a highly expressed islet peptidase that degrades ANG(1-7) to several peptides.
Formal Description
Interaction-ID: 116435

gene/protein

MME

decreases_quantity of

gene/protein

Angiotensin (1-7)

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