General Information:

Id: 11,717 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Graus-Nunes F and Souza-Mello V(2019) The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis Biomed. Pharmacother. 109: 639-645 [PMID: 30404071]

Interaction Information:

Comment The angiotensin 2 (ANG2) receptors are found within the islet, and AT1R is mainly found in the islet core where the beta cells responsible for insulin secretion are located. The angiotensin II type 2 receptor (AT2R) is found in nearby delta cells that secrete somatostatin. Angiotensin-convertingenzyme 2 (ACE2) is expressed by alpha cells and the islet micro-vasculature, though the latter is more implicated in glycemic homeostasis and islet maintenance.
Formal Description
Interaction-ID: 116331




tissue/cell line

pancreatic islet

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