General Information:

Id: 11,684 (click here to show other Interactions for entry)
Diseases: COVID-19
Cardiovascular disease
Rattus norvegicus
article
Reference: [PMID: 26171856]

Interaction Information:

Comment Male rats showed higher cardiac ACE and ACE2 activity as well as hypertrophy compared to female rats.
Formal Description
Interaction-ID: 116061

phenotype

sex

affects_activity of

gene/protein

ACE

in cardiac tissue
Drugbank entries Show/Hide entries for ACE
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 116068

drug/chemical compound

Testosterone

increases_activity of

gene/protein

ACE

in cardiac tissue
Drugbank entries Show/Hide entries for Testosterone or ACE
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 117240

phenotype

sex, male

increases_activity of

gene/protein

ACE

in cardiac tissue; compared to female
Drugbank entries Show/Hide entries for ACE