General Information:

Id: 11,684
Diseases: COVID-19
Cardiovascular disease
Rattus norvegicus
article
Reference: [PMID: 26171856]

Interaction Information:

Comment Male rats showed higher cardiac ACE and ACE2 activity as well as hypertrophy compared to female rats.
Formal Description
Interaction-ID: 116061

phenotype

sex

affects_activity of

gene/protein

ACE

in cardiac tissue
Drugbank entries Show/Hide entries for ACE
Comment Male rats showed higher cardiac ACE and ACE2 activity as well as hypertrophy compared to female rats.
Formal Description
Interaction-ID: 116062

phenotype

sex

affects_activity of

gene/protein

ACE2

in cardiac tissue
Drugbank entries Show/Hide entries for ACE2
Comment Ovariectomy leads to withdrawal of estrogen. It increases cardiac hypertrophy and ACE2 activity, but did not change ACE activity. Gonadectomy, withdrawal of testosterone, has the opposite effect.
Formal Description
Interaction-ID: 116063

drug/chemical compound

Estradiol

decreases_activity of

phenotype

cardiac hypertrophy

Drugbank entries Show/Hide entries for Estradiol
Comment Ovariectomy leads to withdrawal of estrogen. It increases cardiac hypertrophy and ACE2 activity, but did not change ACE activity. Gonadectomy, withdrawal of testosterone, has the opposite effect.
Formal Description
Interaction-ID: 116065

drug/chemical compound

Estradiol

decreases_activity of

gene/protein

ACE2

in cardiac tissue
Drugbank entries Show/Hide entries for Estradiol or ACE2
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 116066

drug/chemical compound

Testosterone

increases_activity of

gene/protein

ACE2

in cardiac tissue
Drugbank entries Show/Hide entries for Testosterone or ACE2
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 116068

drug/chemical compound

Testosterone

increases_activity of

gene/protein

ACE

in cardiac tissue
Drugbank entries Show/Hide entries for Testosterone or ACE
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 116069

phenotype

sex, female

decreases_activity of

gene/protein

ACE2

in cardiac tissue; compared to male
Drugbank entries Show/Hide entries for ACE2
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 116070

phenotype

sex, male

increases_activity of

gene/protein

ACE2

in cardiac tissue; compared to female
Drugbank entries Show/Hide entries for ACE2
Comment Male rats exhibited higher cardiac ACE and ACE2 activity as well as hypertrophy compared to female rats.
Formal Description
Interaction-ID: 116071

phenotype

sex, male

increases_activity of

phenotype

cardiac hypertrophy

compared to female
Comment Male rats exhibited higher ACE2 and ACE ventricular activity than the female rats. Gonadectomy, withdrawal of testosterone, promoted opposite responses in the activity of both enzymes.
Formal Description
Interaction-ID: 117240

phenotype

sex, male

increases_activity of

gene/protein

ACE

in cardiac tissue; compared to female
Drugbank entries Show/Hide entries for ACE