General Information:

Id: 11,681 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus
Metabolic
Mus musculus
male
ACE2 KO mouse; db/db mouse
INS-1 cells
article
Reference: Shi TT et al.(2018) Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells Biochem. Biophys. Res. Commun. 495: 860-866 [PMID: 29128354]

Interaction Information:

Comment ACE2 can suppress mitochondrial membrane potential depolarization which can induce mitochondrial dysfunction and apoptosis in INS-1 cells.
Formal Description
Interaction-ID: 116344

gene/protein

ACE2

decreases_activity of

in INS-1 cells
Drugbank entries Show/Hide entries for ACE2