General Information:

Id: 11,681 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus
Metabolic
Mus musculus
male
ACE2 KO mouse; db/db mouse
INS-1 cells
article
Reference: Shi TT et al.(2018) Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells Biochem. Biophys. Res. Commun. 495: 860-866 [PMID: 29128354]

Interaction Information:

Comment ACE2 over-expression restored glucose-stimulated insulin secretion (GSIS) and mitochondrial membrane potential (MMP) in the presence of H2O2 in INS-1 cells.
Formal Description
Interaction-ID: 116054

gene/protein

ACE2

increases_activity of

the presence of H2O2 in INS-1 cells; ACE2 over-expression restored glucose-stimulated insulin secretion
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 over-expression up-regulated 67 mitochondria-related genes in INS-1 cells.
Formal Description
Interaction-ID: 116144

gene/protein

ACE2

increases_expression of

gene/protein

mitochondria-related genes

in INS-1 cells; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in glucose-stimulated insulin secretion (GSIS).
Formal Description
Interaction-ID: 116147

gene/protein

ACE2

increases_activity of

phenotype

increased intracellular calcium ion level

in islets from db/db mice; when ACE2 is overexpressed, via increased intracellular calcium influx
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 overexpression promotes calcium influx and mitochondrial oxidation, causing an increase in glucose-stimulated insulin secretion (GSIS) in islets.
Formal Description
Interaction-ID: 116149

gene/protein

ACE2

increases_activity of

process

mitochondrial oxidation

in db/db mouse islets; when ACE2 is overexpressed, causing an increase in GSIS
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 can regulate mitochondrial metabolism to increase intracellular calcium influx and improve insulin secretion in pancreatic beta-cells.
Formal Description
Interaction-ID: 116151

gene/protein

ACE2

affects_activity of

process

mitochondrial metabolism

increasing intracellular calcium influx and improving insulin secretion in pancreatic beta-cells
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 over-expression restored glucose-stimulated insulin secretion (GSIS) and mitochondrial membrane potential (MMP) in the presence of H2O2 in INS-1 cells.
Formal Description
Interaction-ID: 116221

gene/protein

ACE2

increases_activity of

the presence of H2O2 in INS-1 cells; ACE2 over-expression restored mitochondrial membrane potential (MMP)
Drugbank entries Show/Hide entries for ACE2
Comment In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in glucose-stimulated insulin secretion (GSIS).
Formal Description
Interaction-ID: 116248

gene/protein

ACE2

decreases_activity of

in islets from db/db mice; when ACE2 is overexpressed, restoring impaired mitochondrial oxidation
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116273

gene/protein

ACE2

increases_expression of

gene/protein

ATP6V1C2

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. To confirm the PCR array data, mRNA levels of ATP6v1e2, COX6c, NDUFA2, and UQCRH were examined. The mRNA levels of ATP6v1e2, COX6c, and NDUFA2 were enhanced in ACE2 plasmid group compared with control. There was no difference in the level of UQCRH between the two groups.
Formal Description
Interaction-ID: 116280

gene/protein

ACE2

increases_expression of

gene/protein

COX6C

in INS-1 cells treated with ACE2 plasmid; also concerning mRNA, when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or COX6C
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. To confirm the PCR array data, mRNA levels of ATP6v1e2, COX6c, NDUFA2, and UQCRH were examined. The mRNA levels of ATP6v1e2, COX6c, and NDUFA2 were enhanced in ACE2 plasmid group compared with control. There was no difference in the level of UQCRH between the two groups.
Formal Description
Interaction-ID: 116282

gene/protein

ACE2

increases_expression of

gene/protein

NDUFA2

in INS-1 cells treated with ACE2 plasmid; also concerning mRNA, when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFA2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. To confirm the PCR array data, mRNA levels of ATP6v1e2, COX6c, NDUFA2, and UQCRH were examined. The mRNA levels of ATP6v1e2, COX6c, and NDUFA2 were enhanced in ACE2 plasmid group compared with control. There was no difference in the level of UQCRH between the two groups.
Formal Description
Interaction-ID: 116283

gene/protein

ACE2

increases_expression of

gene/protein

ATP6V1E2

in INS-1 cells treated with ACE2 plasmid; also concerning mRNA, when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. To confirm the PCR array data, mRNA levels of ATP6v1e2, COX6c, NDUFA2, and UQCRH were examined. The mRNA levels of ATP6v1e2, COX6c, and NDUFA2 were enhanced in ACE2 plasmid group compared with control. There was no difference in the level of UQCRH between the two groups.
Formal Description
Interaction-ID: 116284

gene/protein

ACE2

increases_expression of

gene/protein

UQCRH

in INS-1 cells treated with ACE2 plasmid; but not concerning the mRNA, when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or UQCRH
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116286

gene/protein

ACE2

increases_expression of

gene/protein

ATP5MC3

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116287

gene/protein

ACE2

increases_expression of

gene/protein

COX6A1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116288

gene/protein

ACE2

increases_expression of

gene/protein

ATP6V1G3

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116289

gene/protein

ACE2

increases_expression of

gene/protein

COX7B

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or COX7B
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116295

gene/protein

ACE2

increases_expression of

gene/protein

COX4I1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or COX4I1
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116296

gene/protein

ACE2

increases_expression of

gene/protein

LDHA

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or LDHA
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116298

gene/protein

ACE2

increases_expression of

gene/protein

ATP5F1A

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116299

gene/protein

ACE2

increases_expression of

gene/protein

ATP5F1B

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116301

gene/protein

ACE2

increases_expression of

gene/protein

COX5B

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or COX5B
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116303

gene/protein

ACE2

increases_expression of

gene/protein

NDUFS3

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFS3
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116306

gene/protein

ACE2

increases_expression of

gene/protein

SLC25A10

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or SLC25A10
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116308

gene/protein

ACE2

increases_expression of

gene/protein

B2M

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or B2M
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116309

gene/protein

ACE2

increases_expression of

gene/protein

ATP5MC2

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116311

gene/protein

ACE2

increases_expression of

gene/protein

NDUFA7

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFA7
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116312

gene/protein

ACE2

increases_expression of

gene/protein

NDUFB3

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFB3
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116313

gene/protein

ACE2

increases_expression of

gene/protein

NDUFV2

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFV2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116314

gene/protein

ACE2

increases_expression of

gene/protein

COX8A

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or COX8A
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116317

gene/protein

ACE2

increases_expression of

gene/protein

ATP5ME

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116320

gene/protein

ACE2

increases_expression of

gene/protein

NDUFB6

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFB6
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116321

gene/protein

ACE2

increases_expression of

gene/protein

COX7A2

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116322

gene/protein

ACE2

increases_expression of

gene/protein

ATP5PF

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116325

gene/protein

ACE2

increases_expression of

gene/protein

NDUFS5

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFS5
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116326

gene/protein

ACE2

increases_expression of

gene/protein

ATP4A

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or ATP4A
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116327

gene/protein

ACE2

increases_expression of

gene/protein

NDUFA5

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFA5
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116328

gene/protein

ACE2

increases_expression of

gene/protein

NDUFB7

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFB7
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116330

gene/protein

ACE2

increases_expression of

gene/protein

COX5A

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or COX5A
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116332

gene/protein

ACE2

increases_expression of

gene/protein

ATP6V0A2

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116334

gene/protein

ACE2

decreases_expression of

gene/protein

SDHC

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or SDHC
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116336

gene/protein

ACE2

decreases_expression of

gene/protein

UQCRC1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or UQCRC1
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116337

gene/protein

ACE2

decreases_expression of

gene/protein

NNT

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NNT
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116338

gene/protein

ACE2

decreases_expression of

gene/protein

PPA1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or PPA1
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116339

gene/protein

ACE2

decreases_expression of

gene/protein

NDUFV1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFV1
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116340

gene/protein

ACE2

decreases_expression of

gene/protein

UQCRFS1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or UQCRFS1
Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116342

gene/protein

ACE2

decreases_expression of

gene/protein

NDUFS1

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
Drugbank entries Show/Hide entries for ACE2 or NDUFS1
Comment ACE2 can suppress mitochondrial membrane potential depolarization which can induce mitochondrial dysfunction and apoptosis in INS-1 cells.
Formal Description
Interaction-ID: 116344

gene/protein

ACE2

decreases_activity of

in INS-1 cells
Drugbank entries Show/Hide entries for ACE2
Comment ACE2 can regulate mitochondrial metabolism to increase intracellular calcium influx and improve insulin secretion in pancreatic beta-cells.
Formal Description
Interaction-ID: 116349

gene/protein

ACE2

increases_activity of

in pancreatic beta-cells
Drugbank entries Show/Hide entries for ACE2