General Information:

Id: 11,681 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus
Metabolic
Mus musculus
male
ACE2 KO mouse; db/db mouse
INS-1 cells
article
Reference: Shi TT et al.(2018) Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells Biochem. Biophys. Res. Commun. 495: 860-866 [PMID: 29128354]

Interaction Information:

Comment Via PCR array data is was found that ACE2 overexpression up- and downregulated mitochondria-related genes in INS-1 cells transfected with ACE2 plasmid. 67 genes were upregulated and 17 genes were downregulated.
Formal Description
Interaction-ID: 116286

gene/protein

ACE2

increases_expression of

gene/protein

ATP5MC3

in INS-1 cells treated with ACE2 plasmid; when ACE2 is overexpressed
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