General Information:

Id: 11,681 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus
Metabolic
Mus musculus
male
ACE2 KO mouse; db/db mouse
INS-1 cells
article
Reference: Shi TT et al.(2018) Angiotensin-converting enzyme 2 regulates mitochondrial function in pancreatic beta-cells Biochem. Biophys. Res. Commun. 495: 860-866 [PMID: 29128354]

Interaction Information:

Comment In islets from db/db mice, ACE2 over-expression increased intracellular calcium influx and restored impaired mitochondrial oxidation, potentially causing an increase in glucose-stimulated insulin secretion (GSIS).
Formal Description
Interaction-ID: 116147

gene/protein

ACE2

increases_activity of

phenotype

increased intracellular calcium ion level

in islets from db/db mice; when ACE2 is overexpressed, via increased intracellular calcium influx
Drugbank entries Show/Hide entries for ACE2