General Information:

Id: 11,680 (click here to show other Interactions for entry)
Diseases: Metabolic
Muscular
Mus musculus
ACE2 KO mouse
undifferentiated mouse C2C12 myoblast cells
article/cited
Reference: Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868]

Interaction Information:

Comment The protein levels of lipogenesis proteins ACCalpha and SREBP-1C increased in the ACE2 KO mice, and decreased in the ACE2-overexpressing db/db mice. These results suggested that ACE2 may regulate intramuscular fat accumulate in mice.
Formal Description
Interaction-ID: 116142

gene/protein

ACE2

decreases_quantity of

gene/protein

ACACA

in ACE2-overexpressing db/db mice
Drugbank entries Show/Hide entries for ACE2 or ACACA