General Information:

Id: 11,680 (click here to show other Interactions for entry)
Diseases: Metabolic
Muscular
Mus musculus
ACE2 KO mouse
undifferentiated mouse C2C12 myoblast cells
article/cited
Reference: Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868]

Interaction Information:

Comment ACE2 was overexpressed in the C2C12 cells to evaluate its role in lipid metabolism and ER stress by RT-PCR analysis in vitro. Firstly, ACE2 has been proved to be indeed overexpressed after the adenoviruses infect. Secondly, the mRNA levels of fatty acid oxidation-related genes, PPARalpha, PPARgamma, and CPT1A were increased, and little change was observed in PGC-1alpha and MCAD in ACE2-overexpressing C2C12 cells. The results showed that the overexpression of ACE2 significantly improved fatty acid oxidation and ER stress.
Formal Description
Interaction-ID: 116108

gene/protein

ACE2

increases_expression of

gene/protein

PPARG

in ACE2-overexpressing C2C12 cells; concerning PPARG mRNA; ACE2 has also been proved to be overexpressed after the adenoviruses infect
Drugbank entries Show/Hide entries for ACE2 or PPARG