General Information:

Id: 11,680 (click here to show other Interactions for entry)
Diseases: Metabolic
Muscular
Mus musculus
ACE2 KO mouse
undifferentiated mouse C2C12 myoblast cells
article/cited
Reference: Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868]

Interaction Information:

Comment The ACE2 mRNA levels were indeed reduced in the skeletal muscle of the ACE2 KO mice. They exhibited breakage of fibers and disorder of morphology. The skeletal muscle TG content was significantly higher in ACE2 KO mice than in WT mice.
Formal Description
Interaction-ID: 116098

organism model

ACE2 KO mouse

decreases_expression of

gene/protein

ACE2

in the skeletal muscle of the ACE2 KO mice; concerning ACE2 mRNA content
Drugbank entries Show/Hide entries for ACE2