General Information:

Id: 11,680 (click here to show other Interactions for entry)
Diseases: Metabolic
Muscular
Mus musculus
ACE2 KO mouse
undifferentiated mouse C2C12 myoblast cells
article/cited
Reference: Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868]

Interaction Information:

Comment Activation of ACE2 can ameliorate ER stress and mitochondrial function, which slightly accompanied by reduced TG content and down-regulated the expression of skeletal muscle lipogenic proteins in the db/db mice.
Formal Description
Interaction-ID: 116085

gene/protein

ACE2

increases_activity of

cellular component

mitochondrion

ameliorating mitochondrial function via activation of ACE2
Drugbank entries Show/Hide entries for ACE2