General Information:

Id: 11,680 (click here to show other Interactions for entry)
Diseases: Metabolic
Muscular
Mus musculus
ACE2 KO mouse
undifferentiated mouse C2C12 myoblast cells
article/cited
Reference: Cao X et al.(2019) Angiotensin-converting enzyme 2 regulates endoplasmic reticulum stress and mitochondrial function to preserve skeletal muscle lipid metabolism Lipids Health Dis 18: 207 [PMID: 31775868]

Interaction Information:

Comment Endogenous ACE2 improved lipid metabolism through the IKKbeta/NFkappaB/IRS-1 pathway in skeletal muscle.
Formal Description
Interaction-ID: 116082

gene/protein

ACE2

increases_activity of

process

IKBKB/NFKB1/IRS1 signaling

in mouse skeletal muscle in vivo and in vitro; improving the lipid metabolism
Drugbank entries Show/Hide entries for ACE2