General Information:

Id: 11,676 (click here to show other Interactions for entry)
Diseases: Immunological
SARS-CoV infection
Homo sapiens
HEK293T cells
Reference: Heurich A et al.(2014) TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein J. Virol. 88: 1293-1307 [PMID: 24227843]

Interaction Information:

Comment TMPRSS2, HAT, and hepsin cleave ACE2. Arginine and lysine residues within ACE2 amino acids 697 to 716 are essential for ACE2 cleavage by TMPRSS2 and HAT.
Formal Description
Interaction-ID: 116056



affects_activity of



via proteolytic processing to improve SARS-S-driven transduction
Drugbank entries Show/Hide entries for ACE2