General Information:

Id: 11,676 (click here to show other Interactions for entry)
Diseases: Immunological
SARS-CoV infection
Homo sapiens
HEK293T cells
article
Reference: Heurich A et al.(2014) TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein J. Virol. 88: 1293-1307 [PMID: 24227843]

Interaction Information:

Comment Type II transmembrane serine proteases TMPRSS2 and HAT cleave and activate the spike protein (S) of SARS-CoV so that it can bind to the host receptor angiotensin converting enzyme 2 (ACE2) for membrane fusion. (cited information)
Formal Description
Interaction-ID: 116034

gene/protein

ACE2

increases_activity of

by functioning as receptor for the virus surface protein spike SARS-S
Drugbank entries Show/Hide entries for ACE2