General Information:

Id: 1,162 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
LIKK mouse: mouse selectively expressing constitutively active IKK-beta in hepatocytes; LISR mouse: mouse selectively expressing the I-kappa-B-alpha superrepressor in liver
Reference: Cai D et al.(2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB Nat Med 11: 183-190 [PMID: 15685173]

Interaction Information:

Comment Message levels of NF-kappaB targets were elevated by HFD. mRNAs encoding IL-6, Il-1beta and TNF-alpha were increased by 6.1-, 3.5- and 2.6-fold, respectively. Each of the encoded cytokines has been associated previously with the development of insulin resistance.
Formal Description
Interaction-ID: 7650


high-fat diet

increases_expression of



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