General Information:

Id: 1,154
Diseases: Alzheimer disease - [OMIM]
Amyotrophic lateral sclerosis
Parkinson disease
Mus musculus
APP TgCRND8 (AD animal model), (Thy1)-[A30P]a-SYN (PD/DLB animal model), Tg(SOD1-G93A) ALS model
article
Reference: Letiembre M et al.(2009) Screening of innate immune receptors in neurodegenerative diseases: a similar pattern Neurobiol. Aging 30: 759-768 [PMID: 17905482]

Interaction Information:

Comment The regulation of TLR's (toll-like receptors) and CD14 (LPS receptor) transcripts in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models were analysed. TLR2 and CD14 are the two transcripts constantly upregulated in all three mouse models.
Formal Description
Interaction-ID: 7541

increases_expression of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment The regulation of TLR's (toll-like receptors) and CD14 (LPS receptor) transcripts in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models were analysed. TLR2 and CD14 are the two transcripts constantly upregulated in all three mouse models.
Formal Description
Interaction-ID: 7546

increases_expression of

gene/protein

CD14

Comment The regulation of TLR's (toll-like receptors) and CD14 (LPS receptor) transcripts in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models were analysed. TLR2 and CD14 are the two transcripts constantly upregulated in all three mouse models.
Formal Description
Interaction-ID: 7553

disease

Amyotrophic lateral sclerosis

increases_expression of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment The regulation of TLR's (toll-like receptors) and CD14 (LPS receptor) transcripts in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models were analysed. TLR2 and CD14 are the two transcripts constantly upregulated in all three mouse models.
Formal Description
Interaction-ID: 7555

disease

Amyotrophic lateral sclerosis

increases_expression of

gene/protein

CD14

Comment The regulation of TLR's (toll-like receptors) and CD14 (LPS receptor) transcripts in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models were analysed. TLR2 and CD14 are the two transcripts constantly upregulated in all three mouse models.
Formal Description
Interaction-ID: 7556

disease

Parkinson disease

increases_expression of

gene/protein

TLR2

Drugbank entries Show/Hide entries for TLR2
Comment The regulation of TLR's (toll-like receptors) and CD14 (LPS receptor) transcripts in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models were analysed. TLR2 and CD14 are the two transcripts constantly upregulated in all three mouse models.
Formal Description
Interaction-ID: 7557

disease

Parkinson disease

increases_expression of

gene/protein

CD14

Comment Immunohistochemistry showed that double staining with CD14 and the macrophage/microglial marker AIF1 (IBA1) allowed attribution of CD14 to mononuclear macrophages in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models.
Formal Description
Interaction-ID: 7559

gene/protein

CD14

is_expressed_in

tissue/cell line

microglia

Comment Immunohistochemistry showed that double staining with CD14 and the macrophage/microglial marker AIF1 (IBA1) allowed attribution of CD14 to mononuclear macrophages in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models.
Formal Description
Interaction-ID: 7560

gene/protein

CD14

interacts (colocalizes) with

gene/protein

AIF1

in microglia
Comment Immunohistochemistry showed that double staining with CD14 and the macrophage/microglial marker AIF1 (IBA1) allowed attribution of CD14 to mononuclear macrophages in AD (Alzheimer's disease), PD (Parkinson's disease) and ALS (amyotrophic lateral sclerosis) mouse models.
Formal Description
Interaction-ID: 7628

gene/protein

AIF1

is_expressed_in

tissue/cell line

microglia

Comment The toll-like receptors (TLR's), in this attempt TLR2 and the LPS receptor CD14 are known to trigger a massive inflammatory host response.
Formal Description
Interaction-ID: 8245

gene/protein

CD14

affects_activity of

Comment The toll-like receptors (TLR's), in this attempt TLR2 and the LPS receptor CD14 are known to trigger a massive inflammatory host response.
Formal Description
Interaction-ID: 8246

gene/protein

TLR2

affects_activity of

Drugbank entries Show/Hide entries for TLR2