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Field	Query

	Field	Term

General Information:

Id:	11,431
Diseases:	Cardiovascular disease
Organism:	Mus musculus
Publication type:	article
Reference:	Trinath J et al.(2014) The WNT signaling pathway contributes to dectin-1-dependent inhibition of Toll-like receptor-induced inflammatory signature Mol. Cell. Biol. 34: 4301-4314 [PMID: 25246634]

Interaction Information:

Comment	Dectin-1 activation robustly dampens TLR-induced proinflammatory signature in macrophages.
Formal Description Interaction-ID: 114202	gene/protein CLEC7A decreases_activity of process toll-like receptor signaling pathway

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114260	gene/protein CLEC7A increases_activity of gene/protein PIAS1

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114261	gene/protein CLEC7A increases_activity of gene/protein SOCS1

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114262	gene/protein SOCS1 decreases_activity of gene/protein IRAK1

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114263	gene/protein SOCS1 decreases_activity of gene/protein IRAK4
Drugbank entries	Show/Hide entries for IRAK4
Drugbank DB08590	1-(3-HYDROXYPROPYL)-2-[(3-NITROBENZOYL)A ... not specified IRAK4

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114264	gene/protein SOCS1 decreases_activity of gene/protein MYD88

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114265	gene/protein PIAS1 decreases_activity of gene/protein IRAK1

Comment	Dectin-1-induced PIAS-1 and SOCS-1 negatively influence TLR signaling by targeting IRAK-1, IRAK-4, and MyD88. While SOCS-1 targeted IRAK-1, IRAK-4, and MyD88 for proteasomal degradation, PIAS-1 was found to target IRAK-1 and MyD88.
Formal Description Interaction-ID: 114266	gene/protein PIAS1 decreases_activity of gene/protein MYD88

Comment	Activation of dectin-1 receptor with curdlan led to an increase in phosphorylation of Syk and subsequently induced production of ROS and led to the expression of PIAS-1 and SOCS-1.
Formal Description Interaction-ID: 114267	gene/protein CLEC7A increases_phosphorylation of gene/protein SYK
Drugbank entries	Show/Hide entries for SYK
Drugbank DB02010	Staurosporine not specified SYK
Drugbank DB06834	N-(2-hydroxy-1,1-dimethylethyl)-1-methyl ... not specified SYK
Drugbank DB07159	6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl) ... not specified SYK
Drugbank DB07194	2-{2-[(3,5-dimethylphenyl)amino]pyrimidi ... not specified SYK
Drugbank DB08361	2-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[ ... not specified SYK
Drugbank DB02010	Staurosporine not specified SYK

Comment	Dectin-1 receptor was essential for curdlan-induced expression of WNT5A.
Formal Description Interaction-ID: 114268	gene/protein CLEC7A increases_expression of gene/protein WNT5A

Comment	Overexpression of WNT5A led to augmented expression of curdlan-induced PIAS-1 and SOCS-1.
Formal Description Interaction-ID: 114269	gene/protein WNT5A increases_expression of gene/protein PIAS1

Comment	Overexpression of WNT5A led to augmented expression of curdlan-induced PIAS-1 and SOCS-1.
Formal Description Interaction-ID: 114270	gene/protein WNT5A increases_expression of gene/protein PIAS1

Comment	Dectin-1-induced expression of WNT5A led to the activation of CAMKII, TAK1, and Pyk2, which was further validated by genetic knock-down of WNT5A by specific siRNA.
Formal Description Interaction-ID: 114271	gene/protein WNT5A increases_activity of gene/protein MAP3K7

Comment	Dectin-1-induced expression of WNT5A led to the activation of CAMKII, TAK1, and Pyk2, which was further validated by genetic knock-down of WNT5A by specific siRNA.
Formal Description Interaction-ID: 114272	gene/protein WNT5A increases_activity of complex/PPI Calcium/calmodulin-dependent protein kinase type II

Comment	Dectin-1-induced expression of WNT5A led to the activation of CAMKII, TAK1, and Pyk2, which was further validated by genetic knock-down of WNT5A by specific siRNA.
Formal Description Interaction-ID: 114273	gene/protein WNT5A increases_activity of gene/protein PTK2B
Drugbank entries	Show/Hide entries for PTK2B
Drugbank DB01097	Leflunomide antagonist PTK2B
Drugbank DB01645	Genistein not specified PTK2B
Drugbank DB08341	4-{[4-{[(1R,2R)-2-(dimethylamino)cyclope ... not specified PTK2B
Drugbank DB01645	Genistein not specified PTK2B

Comment	There is increased nuclear translocation of NF-kappaB in macrophages upon engagement of dectin-1 receptor with curdlan via the WNT-Ca2+/CAMKII-TAK1 axis.
Formal Description Interaction-ID: 114274	gene/protein CLEC7A affects_activity of complex/PPI NF-kappaB complex

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