General Information:

Id: 1,112 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
transgenic hAPP/TGFbeta1 mouse
article
Reference: Wyss-Coray T et al.(2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat. Med. 7: 612-618 [PMID: 11329064]

Interaction Information:

Comment CAA severity correlated positively with TGF-beta1 mRNA levels, as well as with Abeta immunoreactivity in the blood vessels. But some AD cases had essentially no cerebrovascular amyloidosis or cerebral amyloid angiopathy (CAA) with deposition of Abeta almost exclusively in plaques. In some AD cases with severe CAA often had relatively little amyloid deposition in plaques.
Formal Description
Interaction-ID: 7220

gene/protein

TGFB1

affects_activity of

CAA severity correlated positively with TGF-beta1 mRNA levels;
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