General Information:

Id: 1,112 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
transgenic hAPP/TGFbeta1 mouse
article
Reference: Wyss-Coray T et al.(2001) TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice Nat. Med. 7: 612-618 [PMID: 11329064]

Interaction Information:

Comment Here we demonstrate that a modest increase in astroglial TGF-beta1 production in aged transgenic mice expressing the human beta-amyloid precursor protein (hAPP) results in a three-fold reduction in the number of parenchymal amyloid plaques, a 50% reduction in the overall Abeta load in the hippocampus and neocortex, and a decrease in the number of dystrophic neurites.
Formal Description
Interaction-ID: 7126

gene/protein

TGFB1

decreases_quantity of

in aged transgenic hAPP mice brain; if the astroglial TGF-beta1 production is increased
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