General Information:

Id: 1,107 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Dementia
Mammalia
review
Reference: Candore G et al.(2010) Inflammation, cytokines, immune response, apolipoprotein E, cholesterol, and oxidative stress in Alzheimer disease: therapeutic implications Rejuvenation Res 13: 301-313 [PMID: 20462385]

Interaction Information:

Comment Increased cholesterol leads to increased cleavage of APP and increased Abeta production.
Formal Description
Interaction-ID: 82834

decreases_quantity of

gene/protein

APP

via increased APP cleavage
Drugbank entries Show/Hide entries for APP