General Information:

Id: 1,105
Diseases: Parkinson disease
Mammalia
article/cited
Reference: Kim SR et al.(2010) Prothrombin kringle-2 induces death of mesencephalic dopaminergic neurons in vivo and in vitro via microglial activation J. Neurosci. Res. 88: 1537-1548 [PMID: 20025058]

Interaction Information:

Comment Activated microglia produce inflammatory mediators, such as inducible nitric oxide synthase, cyclooxygenase-2 and proinflammatory cytokines, including interleukin 1, IL-6 and tumor necrosis factor alpha. (cited information)
Formal Description
Interaction-ID: 7012

increases_quantity of

gene/protein

NOS2

Drugbank entries Show/Hide entries for NOS2
Comment Activated microglia produce inflammatory mediators, such as inducible nitric oxide synthase, cyclooxygenase-2 and proinflammatory cytokines, including interleukin 1, IL-6 and tumor necrosis factor alpha. (cited information)
Formal Description
Interaction-ID: 7014

increases_quantity of

gene/protein

PTGS2

Drugbank entries Show/Hide entries for PTGS2
Comment Activated microglia produce inflammatory mediators, such as inducible nitric oxide synthase, cyclooxygenase-2 and proinflammatory cytokines, including interleukin 1, IL-6 and tumor necrosis factor alpha. (cited information)
Formal Description
Interaction-ID: 7015

increases_quantity of

gene/protein

IL1B

Drugbank entries Show/Hide entries for IL1B
Comment Activated microglia produce inflammatory mediators, such as inducible nitric oxide synthase, cyclooxygenase-2 and proinflammatory cytokines, including interleukin 1, IL-6 and tumor necrosis factor alpha. (cited information)
Formal Description
Interaction-ID: 7017

increases_quantity of

gene/protein

IL6

Drugbank entries Show/Hide entries for IL6
Comment Activated microglia produce inflammatory mediators, such as inducible nitric oxide synthase, cyclooxygenase-2 and proinflammatory cytokines, including interleukin 1, IL-6 and tumor necrosis factor alpha. (cited information)
Formal Description
Interaction-ID: 7018

increases_quantity of

gene/protein

TNF

Drugbank entries Show/Hide entries for TNF
Comment Increasing evidence supports the theory that activated microglia contributes to dopaminergic (DA) neuronal degeneration in the substantia nigra. (cited information)
Formal Description
Interaction-ID: 7019

increases_activity of

process

neuron death

in substantia nigra
Comment Active microglia have been detected in the SN of Parkinsons disease patients. (cited information)
Formal Description
Interaction-ID: 7021

disease

Parkinson disease

cooccurs with

in substantia nigra
Comment After administration of MPTP or 6-hydroxydopamine active microglia are detected in substantia nigra of animals. (cited information)
Formal Description
Interaction-ID: 7024

increases_activity of

in substantia nigra
Comment After administration of MPTP or 6-hydroxydopamine active microglia are detected in substantia nigra of animals. (cited information)
Formal Description
Interaction-ID: 7027

drug/chemical compound

6-OHDA

increases_activity of

in substantia nigra