Welcome to cider

Field	Query

	Field	Term

General Information:

Id:	10,888
Diseases:	Cardiovascular disease Inflammation
Organism:	Homo sapiens
Organism Model:	Han Chinese population in Taiwan
Publication type:	article
Reference:	Lin YJ et al.(2015) Genetic variants in PLCB4/PLCB1 as susceptibility loci for coronary artery aneurysm formation in Kawasaki disease in Han Chinese in Taiwan Sci Rep 5: 14762 [PMID: 26434682]

Interaction Information:

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110892	gene/protein KCNQ5 affects_activity of phenotype coronary artery aneurysm in individuals with Kawasaki disease

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110906	gene/protein KCNQ5 affects_activity of disease Kawasaki disease

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110908	gene/protein PLCB1 affects_activity of phenotype coronary artery aneurysm in individuals with Kawasaki disease

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110909	gene/protein PLCB1 affects_activity of disease Kawasaki disease

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110911	gene/protein PLCB4 affects_activity of phenotype coronary artery aneurysm in individuals with Kawasaki disease

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110912	gene/protein PLCB4 affects_activity of disease Kawasaki disease

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110946	gene/protein PLCL1 affects_activity of phenotype coronary artery aneurysm
Drugbank entries	Show/Hide entries for PLCL1
Drugbank DB01103	Quinacrine inhibitor PLCL1

Comment	Kawasaki disease (KD) is an acute, inflammatory, and self-limited vasculitis predominantly affecting infants and young children. Coronary artery aneurysm (CAA) is the major complication of KD. Chi-square tests for allelic and genotypic comparisons under the dominant model were performed to identify susceptibility gene loci associated with KD related CAA complications. A cluster of 35 genes that includes KCNQ5, PLCB1, PLCB4, and PLCL1 has been identified.
Formal Description Interaction-ID: 110947	gene/protein PLCL1 affects_activity of disease Kawasaki disease
Drugbank entries	Show/Hide entries for PLCL1
Drugbank DB01103	Quinacrine inhibitor PLCL1

Comment	SNP rs6140791 was identified between PLCB4 and PLCB1. Plasma PLC levels were higher in patients with KD and CC+CG rs6140791 genotypes, and these genotypes were more prevalent in patients with KD who also had CAA.
Formal Description Interaction-ID: 110949	SNP rs6140791 PLCB4/PLCB1 increases_activity of phenotype coronary artery aneurysm in individuals with Kawasaki disease

Comment	Silencing KCNQ5, PLCB1, PLCB4, and PLCL1 inhibited the effect of lipopolysaccharide-induced endothelial cell inflammation with varying degrees of proinflammatory cytokine expression.
Formal Description Interaction-ID: 115331	gene/protein PLCB4 affects_activity of process inflammatory response in HUVECs

Comment	Silencing KCNQ5, PLCB1, PLCB4, and PLCL1 inhibited the effect of lipopolysaccharide-induced endothelial cell inflammation with varying degrees of proinflammatory cytokine expression.
Formal Description Interaction-ID: 115334	gene/protein KCNQ5 affects_activity of process inflammatory response in HUVECs

Comment	Silencing KCNQ5, PLCB1, PLCB4, and PLCL1 inhibited the effect of lipopolysaccharide-induced endothelial cell inflammation with varying degrees of proinflammatory cytokine expression.
Formal Description Interaction-ID: 115335	gene/protein PLCB1 affects_activity of process inflammatory response in HUVECs

Comment	Silencing KCNQ5, PLCB1, PLCB4, and PLCL1 inhibited the effect of lipopolysaccharide-induced endothelial cell inflammation with varying degrees of proinflammatory cytokine expression.
Formal Description Interaction-ID: 115336	gene/protein PLCL1 affects_activity of process inflammatory response in HUVECs
Drugbank entries	Show/Hide entries for PLCL1
Drugbank DB01103	Quinacrine inhibitor PLCL1

Home
Contact

The Helmholtz Zentrum München Imprint and Privacy Policy apply.

© 2013 - Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH) Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany

Disclaimer: IBIS Databases and associated information are protected by copyright. This server and its associated data and services are for academic, non-commercial use only. The Helmholtz Zentrum München has no liability for the use of results, data or information which have been provided through this server. Neither the use for commercial purposes, nor the redistribution of IBIS database files to third parties nor the distribution of parts of files or derivative products to any third parties is permitted. Commercial users shall contact the Helmholtz Zentrum München for a separate users license.