General Information:

Id: 101 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
BTO:0004488 NSC-34 cell; BTO:0000312 motoneuron
Reference: Nishitoh H et al.(2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1 Genes Dev 22: 1451-1464 [PMID: 18519638]

Interaction Information:

Comment SOD1mut triggers ER stress. SOD1mut (SOD1(A4V), SOD1(G85R), and SOD1(G93A)) but not wild-type SOD1 (SOD1wt) activated IRE1 and PERK.
Formal Description
Interaction-ID: 343

gene/protein mutant


affects_activity of

in motor neurons