|
2,067
|
| 16659 |
Itch
|
|
decreases_quantity of
|
Notch1
|
in HSC (CD150+CD48-KSL); by ubiquitination of Notch1, resulting in increased proteasomal degradation of Notch1
|
in vivo
|
| 27598 |
HSC (CD150+CD48-KSL)
|
|
increases_quantity of
|
Notch1
|
in Itch-/- mice compared to WT mice
|
in vivo
|
| 27603 |
Itch
|
|
interacts (colocalizes) with
|
Notch1
|
|
in vivo
|
|
21478879
|
|
2,068
|
| 16653 |
Notch1
|
|
increases_activity of
|
cell cycle
|
if the intracellular domain of Notch1 is overexpressed
|
|
| 16654 |
Notch1
|
|
decreases_activity of
|
quiescence
|
if the intracellular domain of Notch1 is overexpressed
|
|
| 16658 |
Itch
|
|
increases_ubiquitination/sumoylation of
|
Notch1
|
|
|
|
21478879
|
|
2,091
|
| 16922 |
MPP (Thy1-CD135+KSL)
|
|
increases_expression of
|
Notch1
|
compared to LT-HSC (Thy1(lo)Flk2-KSL)
|
|
|
16151515
|
|
2,093
|
| 16968 |
MPP (Thy1-CD135+KSL)
|
|
increases_expression of
|
Notch1
|
compared to ST-HSC (Thy1(lo)Flk2+KSL)
|
|
|
16151515
|
|
2,102
|
| 17198 |
Notch1
|
|
increases_activity of
|
self-renewal
|
|
|
|
16151515
|
|
2,148
|
| 19640 |
HSC (CD34-SP,KSL)
|
|
increases_expression of
|
Notch1
|
compared to main bone marrow population
|
|
|
12228720
|
|
2,171
|
| 19639 |
neural stem cell
|
|
increases_expression of
|
Notch1
|
compared to differentiated cells from lateral ventricles
|
|
|
12228720
|
|
2,819
|
| 25977 |
Notch1
|
|
interacts (colocalizes) with
|
Jag1
|
|
|
| 25979 |
Notch1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 25984 |
HSC (KSL)
|
|
increases_quantity of
|
Notch1
|
after PPR activation
|
in vivo
|
| 31811 |
Notch1
|
|
interacts (colocalizes) with
|
Dll1
|
|
|
|
14574413
|
|
2,862
|
| 26461 |
HSC (KSL)
|
|
increases_expression of
|
Notch1
|
in response to to extrinsic factor Ebf2
|
|
|
20887955
|
|
2,878
|
| 26526 |
HSC (CD34-KSL)
|
|
increases_expression of
|
Notch1
|
in Wif1-overexpressing osteoblasts. Expression is up-regulated after 5-FU-treatment
|
in vivo
|
| 26549 |
Wif1
|
|
increases_expression of
|
Notch1
|
in HSC (CD34-KSL), if Wif1-overexpressing osteoblasts are present. Expression is up-regulated after 5-FU-treatment
|
in vivo
|
|
21652676
|
|
3,125
|
| 28736 |
Nfya
|
|
increases_expression of
|
Notch1
|
in HSC (CD150+CD48-KSL)
|
in vivo
|
| 28795 |
HSC (CD150+CD48-KSL)
|
|
increases_expression of
|
Notch1
|
NF-Ya deletion reduces the expression
|
in vivo
|
|
22072554
|
|
3,188
|
| 29271 |
Ctnnb1
|
|
increases_expression of
|
Notch1
|
in HSC (Thy1(lo)KSL)
|
|
| 29273 |
HSC (Thy1(lo)KSL)
|
|
increases_expression of
|
Notch1
|
Expression is further inceased by addition of beta-catenin
|
|
| 29275 |
canonical Wnt signaling pathway
|
|
increases_expression of
|
Notch1
|
in HSC (Thy1(lo)KSL)
|
|
|
12717450
|
|
3,403
|
| 31938 |
Jag1
|
|
interacts (colocalizes) with
|
Notch1
|
|
|
|
20959605
|
|
3,421
|
| 31812 |
Notch1
|
|
increases_quantity of
|
HSC (Sca1+Lin-)
|
in BM
|
in vivo
|
| 31916 |
Notch1
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (Sca1+Lin-)
|
in vivo
|
| 31917 |
Notch1
|
|
increases_activity of
|
self-renewal
|
of HSC (Sca1+Lin-)
|
in vivo
|
| 31924 |
Notch1
|
|
increases_activity of
|
repopulation, lymphoid-biased
|
|
in vivo
|
|
11895769
|
|
3,436
|
| 38884 |
Notch1
|
NOT |
affects_quantity of
|
HSC (KSL)
|
under steady-state conditions
|
in vivo
|
| 38886 |
Notch1
|
NOT |
affects_activity of
|
BM homeostasis
|
|
in vivo
|
|
15550486
|
|
3,594
|
| 33690 |
Junb
|
|
increases_expression of
|
Notch1
|
in in HSC (CD135-KSL)
|
|
| 33696 |
HSC (CD135-KSL)
|
|
increases_expression of
|
Notch1
|
|
|
|
19345332
|
|
3,673
|
| 35198 |
HSC (CD34-CD135-KSL)
|
|
increases_expression of
|
Notch1
|
if LT-HSC (CD34-CD135-KSL) has been cocultured with ECs
|
in vitro
|
|
20207228
|
|
3,811
|
| 38107 |
HSC (CD34-CD127-CD135-CD150+CD48-CD106+KSL)
|
|
increases_quantity of
|
Notch1
|
Expression further increased as cells differentiate towards CLPs.
|
|
| 38118 |
Dll4
|
|
interacts (colocalizes) with
|
Notch1
|
to induce Notch signaling
|
|
| 38119 |
Notch1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 38159 |
Notch1
|
|
affects_activity of
|
lymphoid progenitor cell differentiation
|
Loss of Notch1 rescued the lymphoid differentiation.
|
in vivo
|
|
23134786
|
|
3,826
|
| 38295 |
Fancg
|
|
decreases_expression of
|
Notch1
|
In Fancg-/- KSL cells expression of Notch1 is up-regulated.
|
|
| 38312 |
HSC (KSL)
|
|
increases_expression of
|
Notch1
|
|
|
|
21968513
|
|
3,839
|
| 38539 |
Nfya
|
|
increases_expression of
|
Notch1
|
in Lin-Sca+ cells, if Nfya has been overexpressed
|
|
| 38543 |
HSC (Sca1+Lin-)
|
|
increases_expression of
|
Notch1
|
|
|
|
16081537
|
|
3,869
|
| 38926 |
Dll1
|
|
interacts (colocalizes) with
|
Notch1
|
|
|
| 38931 |
Notch1
|
NOT |
affects_activity of
|
repopulation >16 weeks
|
under homeostatic conditions
|
in vivo
|
| 38933 |
Notch1
|
NOT |
affects_activity of
|
self-renewal
|
under homeostatic conditions
|
in vivo
|
|
21285514
|
|
4,277
|
| 43785 |
Mysm1
|
|
decreases_expression of
|
Notch1
|
in KSL cells
|
|
|
24014243
|
HSC