|
1,930
|
| 14975 |
Cxcr4
|
|
interacts (colocalizes) with
|
Cxcl12
|
to retain HSCs in BM niches
|
|
|
21211783
|
|
2,432
|
| 22199 |
nucleated erythrocyte
|
|
increases_expression of
|
Cxcl12
|
compared to other lymphoid cells or myeloid cells and LT-HSC (SP, KSL)
|
|
|
18371395
|
|
2,761
|
| 25584 |
CAR cell
|
|
increases_expression of
|
Cxcl12
|
|
in vivo
|
|
20850355
|
|
2,766
|
| 25616 |
Cxcl12
|
|
interacts (colocalizes) with
|
Cxcr4
|
|
|
| 25636 |
Cxcl12
|
|
increases_activity of
|
CXCL12/CXCR4 signaling
|
|
in vivo
|
| 25648 |
CAR cell
|
|
increases_quantity of
|
Cxcl12
|
|
in vivo
|
|
17174120
|
|
2,824
|
| 26080 |
PTH signaling
|
|
increases_quantity of
|
Cxcl12
|
in osteoblast (osteopontin)
|
|
| 26083 |
osteoblast (osteopontin+)
|
|
increases_quantity of
|
Cxcl12
|
in the transgenic stroma; via PPR induction
|
|
|
14574413
|
|
2,830
|
| 26133 |
trabecular bone (Col2.3-GFP+)
|
|
increases_expression of
|
Cxcl12
|
in response to irradiation
|
|
| 26148 |
irradiation
|
|
increases_expression of
|
Cxcl12
|
in trabecular bone area
|
|
|
19052548
|
|
2,856
|
| 26374 |
primary MSC-enriched cell (Alcam-Sca1+)
|
|
increases_expression of
|
Cxcl12
|
|
|
|
20472830
|
|
2,878
|
| 26541 |
osteoblast
|
|
increases_expression of
|
Cxcl12
|
in Wif1-overexpressing osteoblasts. Expression is not influenced by 5-FU treatment
|
in vivo
|
| 26543 |
Wif1
|
|
increases_expression of
|
Cxcl12
|
in Wif1-overexpressing osteoblasts. Expression is not influenced by 5-FU treatment
|
in vivo
|
|
21652676
|
|
2,937
|
| 26833 |
mir-886-3p
|
|
decreases_expression of
|
Cxcl12
|
in BM stromal cells; by directly binding to the 3' UTR of Cxcl12 mRNA
|
in vitro
|
|
21179442
|
|
3,117
|
| 28697 |
osteoblastic bone-lining cell (CD45-Ter119-CD31-)
|
|
increases_expression of
|
Cxcl12
|
in RelB/Nfkb2 double knockout mice expression is reduced compared to WT mice
|
|
| 28709 |
RelB/NF-kappaB signaling
|
|
increases_expression of
|
Cxcl12
|
in osteoblastic bone-lining cell (CD45-Ter119-CD31-)
|
|
|
22290873
|
|
3,138
|
| 28901 |
Cxcl12
|
|
increases_quantity of
|
Mmp9
|
in stromal and hematopoietic cells
|
in vivo
|
| 30544 |
5-FU
|
|
increases_quantity of
|
Cxcl12
|
in plasma
|
in vivo
|
|
12062105
|
|
3,182
|
| 29207 |
MSC (Nes+)
|
|
increases_expression of
|
Cxcl12
|
in contrast to osteoblasts or osteoclasts
|
|
| 29220 |
MSC (Nes+)
|
|
increases_expression of
|
Cxcl12
|
in comparison to unlabeled MSC (Nes-GFP-) cells. Expression is down-regulated after addition of G-CSF.
|
in vivo
|
|
20703299
|
|
3,262
|
| 30479 |
Robo4
|
|
decreases_expression of
|
Cxcl12
|
in BM stromal cells; Loss of Robo4 is compensated by upregulating Cxcr4 and Cxcl12.
|
in vivo
|
|
21211783
|
|
3,322
|
| 30533 |
Cxcl12
|
|
increases_activity of
|
quiescence
|
|
in vitro
|
| 30534 |
Cxcl12
|
|
decreases_activity of
|
cell cycle
|
|
in vitro
|
| 30537 |
Cxcl12
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD135-CD48-KSL)
|
in vitro
|
| 30674 |
Cxcl12
|
|
increases_activity of
|
non-cell autonomous activity
|
|
|
|
18378795
|
|
3,337
|
| 30646 |
Hyaluronate
|
|
increases_quantity of
|
Cxcl12
|
|
in vitro
|
|
22654110
|
|
3,373
|
| 31400 |
Csf3
|
|
decreases_quantity of
|
Cxcl12
|
in the bone. The amount of Cxcl12 was not affected in Cgt knockout mice
|
in vivo
|
| 31405 |
Csf3
|
|
decreases_expression of
|
Cxcl12
|
in the BM and bone
|
in vivo
|
|
16439213
|
|
3,378
|
| 31435 |
Anxa2
|
|
increases_quantity of
|
Cxcl12
|
in bone marrow
|
in vivo
|
| 31436 |
Anxa2
|
|
increases_expression of
|
Cxcl12
|
in osteoblasts
|
|
| 31441 |
Anxa2
|
|
interacts (colocalizes) with
|
Cxcl12
|
This interaction facilitates presentation of Cxcl12 to HSCs
|
in vitro
|
| 31444 |
Cxcl12
|
|
is_part_of
|
Anxa2-Cxcl12 complex
|
|
|
| 31445 |
Anxa2
|
|
affects_activity of
|
Cxcl12
|
|
in vitro
|
| 31447 |
Cxcl12
|
|
increases_activity of
|
cell migration
|
but the effect on cell migration is much higher if Anxa2 is bound to Cxcl12. Cell migration in Anxa2+/+ mice is faster than in Anxa2-/- mice.
|
in vitro
|
| 31448 |
Cxcl12
|
|
increases_activity of
|
Erk signaling
|
in HSC (KSL)
|
in vitro
|
| 31450 |
osteoblast
|
|
increases_expression of
|
Cxcl12
|
|
|
| 36495 |
endosteum (Annexin2+)
|
|
increases_expression of
|
Cxcl12
|
|
|
| 36496 |
Cxcl12
|
|
increases_activity of
|
CXCL12/CXCR4 signaling
|
|
|
|
21108988
|
|
3,402
|
| 31583 |
Mmp2
|
|
increases_processing of
|
Cxcl12
|
by removing a tetrapeptide from the N-terminus of SDF1
|
in vitro
|
|
11571304
|
|
3,403
|
| 31638 |
BM cell (CD45-SSEA4+Angpt3+)
|
|
increases_expression of
|
Cxcl12
|
in comparison to CD45-SSEA4+ cells
|
|
|
20959605
|
|
3,583
|
| 33571 |
perivascular cell (Lepr+)
|
|
increases_expression of
|
Cxcl12
|
|
|
|
22281595
|
|
3,680
|
| 35304 |
non-myelinated Schwann cell (GFAP+)
|
|
increases_expression of
|
Cxcl12
|
|
|
|
22118468
|
|
3,682
|
| 35330 |
Csf3
|
|
decreases_expression of
|
Cxcl12
|
in BM
|
|
| 35331 |
Gja1
|
|
increases_transport of
|
Cxcl12
|
in BM, thus facilitating the homing efficiency
|
in vivo
|
| 35333 |
Gjc1
|
|
increases_transport of
|
Cxcl12
|
in BM, thus facilitating the homing efficiency
|
in vivo
|
| 35335 |
Gjc1
|
|
increases_expression of
|
Cxcl12
|
by localizing the transcription factor Sp1 to the nucleus
|
|
| 35336 |
Gja1
|
|
increases_expression of
|
Cxcl12
|
by localizing the transcription factor Sp1 to the nucleus
|
|
| 35339 |
Sp1
|
|
increases_expression of
|
Cxcl12
|
|
|
|
21441933
|
|
3,684
|
| 35342 |
Ca2+
|
|
increases_transport of
|
Cxcl12
|
|
in vitro
|
|
21441933
|
|
3,687
|
| 35479 |
Prostaglandin E2
|
|
increases_expression of
|
Cxcl12
|
in MSC (Nes+) cells known to co-localize with HSC (CD150+CD48-Lin-)
|
|
| 37314 |
MSC (Nes+)
|
|
increases_expression of
|
Cxcl12
|
|
|
|
22983360
|
|
3,689
|
| 35497 |
monocyte (Gr-1+/-)-macrophage (CD169+)
|
|
affects_expression of
|
Cxcl12
|
in BM stromal cells (CD45-). Cxcl12 is not expressed in monocytes/macrophages itself
|
|
| 35506 |
MSC (Nes+)
|
|
increases_expression of
|
Cxcl12
|
Expression of Cxcl12 was reduced after monocyte/macrophage depletion.
|
|
| 37315 |
macrophage (CD169+)
|
|
increases_quantity of
|
Cxcl12
|
in the BM stroma
|
|
|
21282381
|
|
3,690
|
| 35518 |
macrophage (CD169+)
|
|
increases_expression of
|
Cxcl12
|
in BM stromal cells
|
|
|
21282381
|
|
3,693
|
| 35554 |
osteoblast
|
|
increases_expression of
|
Cxcl12
|
expression is reduced after G-CSF treatment
|
|
| 35558 |
Csf3
|
|
decreases_expression of
|
Cxcl12
|
in osteoblasts
|
|
|
20713966
|
|
3,803
|
| 37815 |
Jam2
|
|
decreases_quantity of
|
Cxcl12
|
in the bone marrow
|
in vivo
|
| 38002 |
Cxcl12
|
|
decreases_quantity of
|
Cxcr4
|
in HSC (CD150+CD48-CD41-Lin-)
|
|
|
21868569
|
|
3,833
|
| 38435 |
Crebbp
|
|
decreases_expression of
|
Cxcl12
|
in HSC (KSL) cells
|
|
| 38442 |
HSC (KSL)
|
|
increases_expression of
|
Cxcl12
|
The expression is highly up-regulated in Cbp-deficient mice
|
|
|
22006020
|
|
3,849
|
| 38626 |
Mmp14
|
|
increases_quantity of
|
Cxcl12
|
in the plasma, by inhibiting FIH (Hif1an) activity
|
|
| 38632 |
Hif1a
|
|
increases_expression of
|
Cxcl12
|
|
|
|
22544701
|
HSC