|
2,090
|
| 16909 |
HSC (Thy1(lo)CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
compared to ST-HSC (Thy1(lo)Flk2+KSL)
|
|
|
16151515
|
|
2,092
|
| 16950 |
HSC (Thy1(lo)CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
compared to MPP (Thy1-Flk2+KSL)
|
|
|
16151515
|
|
2,095
|
| 17046 |
HSC (Thy1(lo)CD135+KSL)
|
|
increases_expression of
|
Cdkn1c
|
compared to MPP (Thy1-Flk2+KSL)
|
|
|
16151515
|
|
2,569
|
| 24176 |
HSC (CD34-Mpl+KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
in vivo
|
| 24179 |
HSC (SP,KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
in vivo
|
|
18371409
|
|
2,622
|
| 24897 |
Thpo
|
|
increases_expression of
|
Cdkn1c
|
in HSC (Mpl+KSL)
|
in vivo
|
|
18371409
|
|
2,626
|
| 24942 |
Thpo
|
|
increases_expression of
|
Cdkn1c
|
in FLT3-KSL HSCs
|
in vivo
|
| 24944 |
HSC (CD34-CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
in vivo
|
|
18371408
|
|
3,018
|
| 27669 |
HSC (Thy1(lo)Rho(lo)KSL
|
|
increases_expression of
|
Cdkn1c
|
in comparison to MPP (Thy1(lo)Rho(hi)KSL), CLP (IL7r+Kit(lo)Sca1(lo)) or CMP (IL7r-Kit+Sca1-CD34+Fc(gamma)RII/III+)
|
|
|
12393558
|
|
3,031
|
| 27863 |
HSC (Thy1(lo)CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
compared to mobilized HSCs, MPPs and Leukemic HSCs
|
|
|
20098702
|
|
3,111
|
| 28572 |
Stat5a
|
|
increases_expression of
|
Cdkn1c
|
within the HSC (KSL) pool
|
in vivo
|
|
19258595
|
|
3,207
|
| 29549 |
Skp2
|
|
decreases_quantity of
|
Cdkn1c
|
by ubiquitination and proteasomal degradation
|
|
| 29550 |
Cdkn1c
|
|
decreases_activity of
|
cell cycle
|
|
|
|
21502543
|
|
3,241
|
| 29919 |
HSC (KSL)
|
|
increases_expression of
|
Cdkn1c
|
if cocultured with the endosteal cell fraction (ALCAM+Sca1-)
|
|
|
20472830
|
|
3,322
|
| 30536 |
HSC (CD48-CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
| 30537 |
Cxcl12
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD135-CD48-KSL)
|
in vitro
|
| 30541 |
Cxcr4
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD135-CD48-KSL)
|
in vivo
|
| 30542 |
CXCL12/CXCR4 signaling
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD135-CD48-KSL)
|
in vivo
|
|
18378795
|
|
3,594
|
| 33657 |
Junb
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD135-KSL)
|
|
| 33664 |
HSC (CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
| 33676 |
Junb
|
|
increases_expression of
|
Cdkn1c
|
in CD150+CD48-CD135-KSL cells
|
|
| 33682 |
HSC (CD150+CD48-CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
| 33710 |
Tgfb1
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD150+CD48-CD135-KSL); In JunB-deficient mice induction via Tgfbeta is impaired.
|
|
| 33714 |
transforming growth factor beta receptor signaling pathway
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD150+CD48-CD135-KSL); In JunB-deficient mice induction via Tgfbeta is impaired.
|
|
|
19345332
|
|
3,600
|
| 33785 |
Dmtf1
|
|
increases_expression of
|
Cdkn1c
|
in KSL cells
|
|
| 33789 |
HSC (KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
|
22039255
|
|
3,601
|
| 34158 |
Igfbp2
|
|
decreases_expression of
|
Cdkn1c
|
in HSC (KSL)
|
|
| 34162 |
HSC (KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
| 34168 |
Cdkn1c
|
|
decreases_activity of
|
cell cycle
|
|
|
|
21821709
|
|
3,635
|
| 34461 |
Foxo3
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD34-KSL) cells
|
|
| 34463 |
HSC (CD34-KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
|
18371339
|
|
3,793
|
| 37463 |
Ptpmt1
|
|
decreases_expression of
|
Cdkn1c
|
in HSC (CD150+CD48-CD135-KSL)
|
|
| 37466 |
HSC (CD150+CD48-CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
Expression increases after Ptpmt1 deletion
|
|
|
23290137
|
|
3,826
|
| 38308 |
Fancg
|
|
increases_expression of
|
Cdkn1c
|
In Fancg-/- KSL cells expression of p57(Kip2) is down-regulated.
|
|
| 38317 |
HSC (KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
|
21968513
|
|
3,830
|
| 38357 |
Spi1
|
|
increases_expression of
|
Cdkn1c
|
in HSC (CD150+CD48-KSL)
|
|
| 38359 |
Cdkn1c
|
|
decreases_activity of
|
cell cycle
|
|
|
| 38373 |
HSC (CD150+CD48-KSL)
|
|
increases_expression of
|
Cdkn1c
|
|
|
|
23395001
|
|
3,860
|
| 38787 |
Angpt1
|
|
increases_expression of
|
Cdkn1c
|
in HSC (KSL), if Angpt1 is overexpressed in osteoblasts
|
|
|
23149415
|
|
3,861
|
| 38795 |
HSC (CD150+KSL)
|
|
increases_quantity of
|
Cdkn1c
|
in comparison to CD150-KSL cells
|
|
| 38796 |
Cdkn1c
|
|
increases_quantity of
|
HSC (KSL)
|
|
in vivo
|
| 38797 |
Cdkn1c
|
|
increases_quantity of
|
HSC (CD150+CD48-KSL)
|
|
in vivo
|
| 38798 |
Cdkn1c
|
|
increases_quantity of
|
HSC (CD34-KSL)
|
|
in vivo
|
| 38799 |
Cdkn1c
|
|
increases_quantity of
|
HSC (CD34+KSL)
|
|
in vivo
|
| 38800 |
Cdkn1c
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (CD150+CD48-KSL)
|
in vivo
|
| 38802 |
Cdkn1c
|
|
increases_activity of
|
self-renewal
|
of HSC (CD150+CD48-KSL)
|
in vivo
|
| 38805 |
Cdkn1c
|
|
increases_activity of
|
quiescence
|
in KSL cells
|
in vivo
|
| 38808 |
Cdkn1c
|
|
increases_activity of
|
quiescence
|
in CD34-KSL cells or CD34+ksl cells
|
in vivo
|
| 38810 |
Cdkn1c
|
|
decreases_activity of
|
apoptotic process
|
in KSL cells. Loss of p57 results in up-regulation of p53 expression and CDK activity
|
in vivo
|
| 38812 |
Cdkn1c
|
|
decreases_quantity of
|
Trp53
|
in KSL cells. Loss of p57 results in up-regulation of p53 expression and CDK activity
|
|
|
21885021
|
|
3,863
|
| 38833 |
HSC (CD34-CD135-KSL)
|
|
increases_expression of
|
Cdkn1c
|
compared to ST-HSCs and MPPs
|
|
| 38834 |
HSC (CD150+CD48-KSL)
|
|
increases_expression of
|
Cdkn1c
|
compared to ST-HSCs and MPPs
|
|
| 38835 |
HSC (CD34+CD135-KSL)
|
|
decreases_expression of
|
Cdkn1c
|
compared to LT-HSCs
|
|
| 38836 |
Cdkn1c
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
| 38837 |
Cdkn1c
|
|
affects_expression of
|
Cdkn1b
|
in KSL cells 4 month posttransplant. This suggests that p27 compensates for p57 deficiency
|
|
| 38838 |
Cdkn1c
|
|
affects_expression of
|
Cdkn2c
|
in KSL cells 4 month posttransplant
|
|
| 38839 |
Thpo
|
|
increases_expression of
|
Cdkn1c
|
in KSL cells 4 month posttransplant
|
|
| 38853 |
Cdkn1b
|
|
increases_activity of
|
Cdkn1c
|
p27 (Cdkn1b) cooperates with p57 (Cdkn1c) to preserve self-renewal activity of HSCs
|
in vivo
|
| 38856 |
Kitl
|
|
decreases_quantity of
|
Cdkn1c
|
this results in nuclear translocation of cyclin D1
|
in vitro
|
| 38866 |
Cdkn1c
|
|
increases_activity of
|
quiescence
|
together with p27 (Cdkn1b)
|
in vivo
|
|
21885020
|
|
3,864
|
| 38842 |
Cdkn1c
|
|
interacts (colocalizes) with
|
Ccnd2
|
under quiescent conditions
|
|
| 38844 |
Cdkn1c
|
|
interacts (colocalizes) with
|
Ccnd1
|
under quiescent conditions
|
|
| 38845 |
Cdkn1c
|
|
interacts (colocalizes) with
|
Cdk4
|
under quiescent conditions
|
|
| 38847 |
Cdkn1c
|
|
interacts (colocalizes) with
|
Cdk6
|
under quiescent conditions
|
|
| 38848 |
Cdkn1c
|
|
interacts (colocalizes) with
|
Hspa8
|
in CD34-Lin- EML cells, under quiescent conditions
|
|
| 38861 |
Cdkn1c
|
|
interacts (colocalizes) with
|
Ccnd1-Hspa8 complex
|
to preserve HSC quiescence
|
|
| 38863 |
Cdkn1c
|
|
decreases_activity of
|
Ccnd1-Hspa8 complex
|
to preserve HSC quiescence
|
|
|
21885020
|
HSC