|
1,967
|
| 15415 |
HSC (CD150+CD45+CD201+CD48-)
|
|
increases_expression of
|
Bmi1
|
|
|
| 15427 |
HSC (CD150-CD45+CD201+CD48-)
|
|
decreases_expression of
|
Bmi1
|
|
|
|
19377048
|
|
3,017
|
| 27617 |
HSC (Thy1(lo)Rho(lo)KSL)
|
|
increases_expression of
|
Bmi1
|
in comparison to MPP (Thy1(lo)Rho(hi)KSL), CLP (IL7r+Kit(lo)Sca1(lo)) or CMP (IL7r-Kit+Sca1-CD34+Fc(gamma)RII/III+)
|
|
|
12393558
|
|
3,097
|
| 28413 |
Bmi1
|
|
increases_activity of
|
regulation of gene expression, epigenetic
|
|
|
| 28414 |
HSC (CD34-KSL)
|
|
increases_expression of
|
Bmi1
|
in comparison to CD34+KSL cells
|
|
| 28418 |
HSC (CD34+KSL)
|
|
decreases_expression of
|
Bmi1
|
in comparison to CD34-KSL cells
|
|
| 28422 |
Bmi1
|
|
is_part_of
|
Polycomb repressive complex PRC1
|
|
|
| 28491 |
Bmi1
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
| 28495 |
Bmi1
|
|
increases_quantity of
|
HSC (CD34-KSL)
|
|
in vivo
|
| 28496 |
Bmi1
|
|
decreases_expression of
|
Cdkn2a
|
in HSC (Lin-); both isoforms of Cdkn2a, p16(Ink4a) and p19(Arf), are affected
|
in vivo
|
|
15589172
|
|
3,106
|
| 28501 |
HSC (Thy1(lo)KSL)
|
|
increases_expression of
|
Bmi1
|
|
in vivo
|
| 28503 |
HSC (Thy1(lo)Mac1+Sca1+Lin-)
|
|
increases_expression of
|
Bmi1
|
|
in vivo
|
| 28504 |
Bmi1
|
|
increases_quantity of
|
HSC (Thy1(lo)KSL)
|
in bone marrow of adult mice. Number of HSCs in Bmi-/- fetal liver was not affected
|
in vivo
|
| 28505 |
Bmi1
|
|
increases_activity of
|
repopulation <12 weeks
|
of HSC (Thy1(lo)KSL)
|
in vivo
|
| 28506 |
Bmi1
|
|
increases_activity of
|
self-renewal
|
of HSC (Thy1(lo)KSL)
|
in vivo
|
| 28510 |
Bmi1
|
|
decreases_expression of
|
Cdkn2a
|
in BM; both isoforms of Cdkn2a, p16(Ink4a) and p19(Arf), are affected
|
|
| 28513 |
Bmi1
|
|
decreases_expression of
|
Dcn
|
in BM
|
|
| 28514 |
Bmi1
|
|
decreases_expression of
|
Zmat3
|
in BM
|
|
| 28515 |
Bmi1
|
|
decreases_expression of
|
Tjp1
|
in BM
|
|
| 28516 |
Bmi1
|
|
decreases_expression of
|
Ackr3
|
in BM
|
|
| 28517 |
Bmi1
|
|
increases_expression of
|
Myl4
|
in BM
|
|
| 28518 |
Bmi1
|
|
increases_expression of
|
Pou2af1
|
in BM
|
|
| 28519 |
Bmi1
|
|
increases_expression of
|
Irf4
|
in BM
|
|
| 28520 |
Bmi1
|
|
increases_expression of
|
Spib
|
in BM
|
|
| 28521 |
Bmi1
|
|
increases_expression of
|
Cd5l
|
in BM
|
|
| 28525 |
Bmi1
|
|
increases_expression of
|
Pafah1b3
|
in BM
|
|
| 28526 |
Bmi1
|
|
increases_expression of
|
Reln
|
in BM
|
|
| 42463 |
Bmi1
|
NOT |
affects_quantity of
|
HSC (Thy1(lo)Mac1+Sca1+Lin-)
|
in fetal liver. Number of HSCs in Bmi-/- adult bone marrow was reduced
|
in vivo
|
|
12714971
|
|
3,125
|
| 28738 |
Nfya
|
|
increases_expression of
|
Bmi1
|
in HSC (CD150+CD48-KSL)
|
in vivo
|
| 28797 |
HSC (CD150+CD48-KSL)
|
|
increases_expression of
|
Bmi1
|
NF-Ya deletion reduces the expression
|
in vivo
|
|
22072554
|
|
3,727
|
| 36241 |
Bmi1
|
|
increases_activity of
|
gene silencing
|
|
|
| 36243 |
Bmi1
|
|
increases_quantity of
|
HSC (CD34-KSL)
|
under oxidative stress conditions
|
in vitro
|
| 36244 |
Bmi1
|
|
increases_activity of
|
self-renewal
|
if Bmi1 is overexpressed in CD34-KSL cells
|
in vivo
|
| 36246 |
Bmi1
|
|
decreases_activity of
|
response to oxidative stress
|
if Bmi1 is overexpressed in CD34-KSL cells. Unexpectedly, overexpression of Bmi1 has no effect on intracellular ROS level.
|
in vitro
|
| 39698 |
Bmi1
|
|
increases_activity of
|
chromatin organization
|
|
|
| 39775 |
Bmi1
|
|
increases_activity of
|
histone ubiquitination
|
|
|
|
22606246
|
|
3,817
|
| 38258 |
Bmi1
|
|
is_part_of
|
Polycomb repressive complex PRC1
|
|
|
|
19369945
|
|
3,826
|
| 38291 |
Fancg
|
|
increases_expression of
|
Bmi1
|
In Fancg-/- KSL cells expression of Bmi1 is down-regulated.
|
|
| 38311 |
HSC (KSL)
|
|
increases_expression of
|
Bmi1
|
|
|
|
21968513
|
|
3,829
|
| 38338 |
Egr1
|
|
decreases_expression of
|
Bmi1
|
|
|
| 38342 |
HSC (CD135-KSL)
|
|
increases_expression of
|
Bmi1
|
|
|
|
18397757
|
|
3,932
|
| 39927 |
Bmi1
|
|
increases_activity of
|
repopulation <12 weeks
|
Repression of the ink4a/Arf expression is responsible for this effect, since simultaneous deletion of the Ink4a-Arf locus together with Bmi1, restored the repopulation capacity
|
in vivo
|
| 39928 |
Bmi1
|
|
increases_activity of
|
self-renewal
|
Repression of the ink4a/Arf expression is responsible for this effect, since simultaneous deletion of the Ink4a-Arf locus together with Bmi1, restored the repopulation capacity
|
in vivo
|
| 39929 |
Bmi1
|
|
increases_activity of
|
non-cell autonomous activity
|
|
in vivo
|
| 39930 |
Bmi1
|
|
increases_quantity of
|
osteoblast
|
|
in vivo
|
| 39932 |
Bmi1
|
|
decreases_expression of
|
Cdkn2a
|
in osteoblasts
|
|
|
16954369
|
|
4,124
|
| 42469 |
Pcgf2
|
|
affects_activity of
|
Bmi1
|
|
|
| 42474 |
Bmi1
|
|
affects_activity of
|
Pcgf2
|
|
|
|
22634509
|
|
4,125
|
| 42485 |
Bmi1
|
|
decreases_quantity of
|
Reactive oxygen species
|
in KSL cells and thymocytes
|
in vivo
|
| 42487 |
Bmi1
|
|
decreases_quantity of
|
Reactive oxygen species
|
in LT-HSC (CD150+CD48-CD41-KSL), due to impaired mitochondrial function
|
in vivo
|
| 42488 |
Bmi1
|
|
increases_quantity of
|
NADPH
|
in thymocytes
|
|
| 42489 |
Bmi1
|
|
increases_quantity of
|
ATP
|
in thymocytes
|
|
| 42490 |
Bmi1
|
|
increases_activity of
|
cellular response to DNA damage stimulus
|
in thymocytes
|
in vivo
|
|
19404261
|
|
4,134
|
| 42607 |
HSC (CD34-KSL)
|
|
increases_expression of
|
Bmi1
|
in comparison to CD34+KSL cells
|
|
| 42608 |
HSC (CD34+KSL)
|
|
decreases_expression of
|
Bmi1
|
in comparison to CD34-KSL cells
|
|
| 42609 |
E4f1
|
|
interacts (colocalizes) with
|
Bmi1
|
|
in vitro
|
| 42610 |
Bmi1
|
|
decreases_activity of
|
cellular senescence
|
in fetal liver cells
|
in vitro
|
| 42611 |
Bmi1
|
|
decreases_expression of
|
Cdkn2a
|
in fetal liver cells. Expression of the splice-variant p16Ink4a is stronger affected than expression of p19Arf
|
in vitro
|
| 42612 |
Bmi1
|
|
increases_activity of
|
cell cycle
|
in fetal liver cells
|
in vitro
|
| 42613 |
Bmi1
|
|
decreases_activity of
|
cell cycle arrest
|
in fetal liver cells
|
in vitro
|
| 42615 |
E4f1
|
|
affects_activity of
|
Bmi1
|
in fetal liver cells
|
in vitro
|
|
16882984
|
|
4,135
|
| 42623 |
Bmi1
|
|
affects_activity of
|
Leukemia
|
|
|
| 42624 |
Bmi1
|
|
interacts (colocalizes) with
|
Akt1
|
|
in vitro
|
| 42625 |
Akt1
|
|
increases_phosphorylation of
|
Bmi1
|
|
in vitro
|
| 42626 |
Akt2
|
|
increases_phosphorylation of
|
Bmi1
|
|
in vitro
|
| 42627 |
phosphatidylinositol 3-kinase signaling
|
|
decreases_activity of
|
Bmi1
|
|
in vitro
|
| 43831 |
Bmi1
|
|
interacts (colocalizes) with
|
Akt2
|
|
in vitro
|
|
23092893
|
|
4,156
|
| 42867 |
Runx1
|
|
interacts (colocalizes) with
|
Bmi1
|
|
|
|
22325351
|
HSC