|
1,952
|
| 15543 |
dormant-HSC (LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
| 15688 |
active-HSC (non-LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
decreases_activity of
|
self-renewal
|
|
in vivo
|
|
19062086
|
|
1,955
|
| 30867 |
IT-HSC (CD34(lo)CD135-Rho(lo)CD49b(hi)KSL)
|
|
decreases_activity of
|
self-renewal
|
|
in vivo
|
| 34836 |
ST-HSC (CD34(hi)CD135+Rho(hi)KSL)
|
NOT |
affects_activity of
|
self-renewal
|
|
in vivo
|
| 37005 |
LT-HSC (CD34(lo)CD135-Rho(lo)CD49b(lo)KSL)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
20074534
|
|
1,964
|
| 28109 |
HSC (CD150+Thy1(lo)KSL)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
| 34821 |
HSC (CD150+CD48-CD41-KSL)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
| 34822 |
HSC (CD150+CD48-CD244-)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
15989959
|
|
1,967
|
| 15544 |
HSC (CD150+CD45+CD201+CD48-)
|
|
increases_activity of
|
self-renewal
|
in both fetal and adult BM sources
|
in vivo
|
| 28194 |
Prnp
|
|
affects_activity of
|
self-renewal
|
|
|
| 28196 |
Gata3
|
|
affects_activity of
|
self-renewal
|
|
|
| 28197 |
Vwf
|
|
affects_activity of
|
self-renewal
|
|
|
| 28198 |
Rhob
|
|
affects_activity of
|
self-renewal
|
|
|
| 28199 |
Pld3
|
|
affects_activity of
|
self-renewal
|
|
|
| 36985 |
HSC (CD150-CD45+CD201+CD48-)
|
|
decreases_activity of
|
self-renewal
|
in both fetal and adult BM sources
|
in vivo
|
|
19377048
|
|
1,969
|
| 15433 |
HSC (CD150+CD45+CD201+CD48-)
|
|
increases_activity of
|
self-renewal
|
in both fetal and adult BM sources
|
in vivo
|
|
19377048
|
|
1,971
|
| 15454 |
HSCalpha (CD45(mid)lin-Rho-SP)
|
|
increases_activity of
|
self-renewal
|
showing myeloid and lymphoid progenitors as well
|
in vivo
|
| 15457 |
HSCbeta (CD45(mid)lin-Rho-SP)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
| 34834 |
HSCgamma (CD45(mid)lin-Rho-SP)
|
NOT |
affects_activity of
|
self-renewal
|
|
in vivo
|
| 34835 |
HSCdelta (CD45(mid)lin-Rho-SP)
|
NOT |
affects_activity of
|
self-renewal
|
|
in vivo
|
|
18371352
|
|
1,995
|
| 15732 |
My-bi-HSC (lower SP,KSL)
|
|
increases_activity of
|
self-renewal
|
myeloid-biased, with higher self-renewal activity than Ly-HSC (upper-SP-KSL)
|
in vivo
|
| 15733 |
Ly-bi-HSC (upper SP,KSL)
|
|
decreases_activity of
|
self-renewal
|
lymphoid-biased, with lower self-renewal activity than My-HSC (lower-SP-KSL)
|
in vivo
|
|
20207229
|
|
2,059
|
| 16537 |
Vps72
|
|
increases_activity of
|
self-renewal
|
of HSC (CD150+CD48-KSL), if Vps72 is overexpressed
|
in vivo
|
| 16538 |
Klf10
|
|
increases_activity of
|
self-renewal
|
of HSC (CD150+CD48-KSL), if Klf10 is overexpressed
|
in vivo
|
| 16539 |
Erdr1
|
|
increases_activity of
|
self-renewal
|
of HSC (CD150+CD48-KSL), if Erdr1 is overexpressed
|
in vivo
|
|
19379700
|
|
2,067
|
| 16650 |
Itch
|
|
decreases_activity of
|
self-renewal
|
|
in vivo
|
|
21478879
|
|
2,102
|
| 17198 |
Notch1
|
|
increases_activity of
|
self-renewal
|
|
|
|
16151515
|
|
2,211
|
| 24070 |
Ly6a
|
|
increases_activity of
|
self-renewal
|
|
|
|
15459755
|
|
2,569
|
| 24888 |
HSC (CD34-Mpl+KSL)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
18371409
|
|
2,626
|
| 24951 |
Thpo
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
18371408
|
|
2,627
|
| 24957 |
Mpl
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
9448308
|
|
2,656
|
| 25075 |
Mpl
|
|
increases_activity of
|
self-renewal
|
compared to WT or Lnk-/- cells
|
in vivo
|
| 25093 |
Sh2b3
|
|
decreases_activity of
|
self-renewal
|
compared to WT or Mpl-/- cells
|
in vivo
|
|
18618018
|
|
2,744
|
| 25421 |
Sh2b3
|
|
decreases_activity of
|
self-renewal
|
in HSC (CD34-KSL); after TPO treatment
|
in vivo
|
|
17284614
|
|
2,749
|
| 25446 |
Thpo
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
12163458
|
|
2,819
|
| 26089 |
Notch signaling pathway
|
|
increases_activity of
|
self-renewal
|
of HSCs
|
|
|
14574413
|
|
2,834
|
| 26171 |
canonical Wnt signaling pathway
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
| 26321 |
Dkk1
|
|
decreases_activity of
|
self-renewal
|
|
in vivo
|
|
18371452
|
|
2,858
|
| 26410 |
Bmp4
|
|
increases_activity of
|
self-renewal
|
of HSC (KSL)
|
in vivo
|
| 26411 |
BMP signaling pathway
|
|
increases_activity of
|
self-renewal
|
of HSC (KSL)
|
in vivo
|
|
19759357
|
|
2,878
|
| 26519 |
Wif1
|
|
decreases_activity of
|
self-renewal
|
if Wif1 is overexpressed in osteoblasts
|
in vivo
|
|
21652676
|
|
2,940
|
| 26844 |
Casr
|
|
increases_activity of
|
self-renewal
|
of HSC (KSL)
|
in vivo
|
|
16382241
|
|
2,988
|
| 27236 |
HSC (CD135-KSL)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
11672547
|
|
2,995
|
| 27271 |
HSC (Thy1(lo)Sca1+Lin-Mac1-CD4-)
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
7541305
|
|
3,000
|
| 27319 |
My-bi-HSC
|
|
increases_activity of
|
self-renewal
|
My-bi HSC clones showed a delayed onset of repopulation. Whereas 4 of 5 Ly-bi and 5 of 7 balanced HSC clones already contributed to blood 1 month after transplantation, none of the My-bi HSCs clones generated donor-type cells by this time.
|
in vivo
|
| 27320 |
Ly-bi-HSC
|
|
decreases_activity of
|
self-renewal
|
|
in vivo
|
| 40047 |
balanced-HSC
|
|
increases_activity of
|
self-renewal
|
My-bi HSC clones showed a delayed onset of repopulation. Whereas 4 of 5 Ly-bi and 5 of 7 balanced HSC clones already contributed to blood 1 month after transplantation, none of the My-bi HSCs clones generated donor-type cells by this time.
|
in vivo
|
|
14976059
|
|
3,007
|
| 27375 |
HSC (Lin-Rho-SP)
|
|
decreases_activity of
|
self-renewal
|
in comparison to the expansion rate of fetal liver HSCs, with greatest difference in HSC expansion 2 weeks posttransplant
|
in vivo
|
|
17379664
|
|
3,008
|
| 27376 |
HSC (Sca1+CD43+Mac1+lin-)
|
|
increases_activity of
|
self-renewal
|
in comparison to the expansion rate of adult HSCs, with greatest difference in HSC expansion 2 weeks posttransplant
|
in vivo
|
|
17379664
|
|
3,010
|
| 27477 |
HSC (CD150(hi)CD34-KSL)
|
|
increases_activity of
|
self-renewal
|
In most recipients hematopoiesis was sustained for 5 mo after secondary transplantation.
|
in vivo
|
| 27510 |
HSC (CD150(int)CD34-KSL)
|
|
decreases_activity of
|
self-renewal
|
LTRCs were detected in 4 out of 13 cohorts of secondary-recipient mice.
|
in vivo
|
| 27514 |
HSC (CD150-CD34-KSL)
|
NOT |
affects_activity of
|
self-renewal
|
LTRCs were detected in 2 out of 12 cohorts of secondary-recipient mice.
|
in vivo
|
|
20421392
|
|
3,058
|
| 28065 |
HSC (CD34-KSL)
|
|
increases_activity of
|
self-renewal
|
|
|
|
8662508
|
|
3,092
|
| 28397 |
Gab2
|
|
increases_activity of
|
self-renewal
|
Self-renewal activity is synergisically decreased in Stat5/Gab2 double knockout mice.
|
in vivo
|
| 28405 |
Stat5a
|
|
increases_activity of
|
self-renewal
|
Self-renewal activity is synergisically decreased in Stat5/Gab2 double knockout mice.
|
in vivo
|
|
20161778
|
HSC