|
1,952
|
| 15549 |
dormant-HSC (LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
| 28091 |
active-HSC (non-LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
decreases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
19062086
|
|
1,955
|
| 15243 |
IT-HSC (CD34(lo)CD135-Rho(lo)CD49b(hi)KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
decline after 8 weeks
|
in vivo
|
| 24255 |
LT-HSC (CD34(lo)CD135-Rho(lo)CD49b(lo)KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
20074534
|
|
1,964
|
| 15357 |
HSC (CD150+CD48-KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
47% of individually transplanted cells generated LT-multilineage reconstitution.
|
in vivo
|
| 15533 |
HSC (Thy1(lo)KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
20% of individually transplanted cells generated LT-multilineage reconstitution.
|
in vivo
|
| 24212 |
HSC (CD150+CD48-)
|
|
increases_activity of
|
repopulation >16 weeks
|
21% of individually transplanted cells generated LT-multilineage reconstitution.
|
in vivo
|
| 24784 |
HSC (CD150+CD48-CD244-)
|
|
increases_activity of
|
repopulation >16 weeks
|
21% of individually transplanted cells generated LT-multilineage reconstitution.
|
in vivo
|
| 28108 |
HSC (CD150+Thy1(lo)KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
| 37002 |
HSC (CD150+CD48-CD41-KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
15989959
|
|
1,965
|
| 15359 |
HSC (CD150+CD48-)
|
|
increases_activity of
|
repopulation >16 weeks
|
irrespective of the mouse strain (Balb/c, DBA/2 or C57BL)
|
in vivo
|
|
15989959
|
|
1,966
|
| 24220 |
HSC (CD150+CD48-CD41-Lin-)
|
|
increases_activity of
|
repopulation >16 weeks
|
in mobilized spleen; 33% of individually transplanted cells generated long-term multilineage reconstitution
|
in vivo
|
| 24230 |
HSC (CD150+CD48-CD41-Lin-)
|
|
increases_activity of
|
repopulation >16 weeks
|
in bone marrow; 45% of individually transplanted cells generated long-term multilineage reconstitution
|
in vivo
|
| 29358 |
HSC (CD150+CD48-CD41-KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
in bone marrow; Almost all (CD150+CD48-CD41-) cells express the KSL markers. Therefore addition of KSL markers to SLAM markers for purification adds only little additional purity.
|
in vivo
|
|
15989959
|
|
1,967
|
| 15405 |
HSC (CD150+CD45+CD201+CD48-)
|
|
increases_activity of
|
repopulation >16 weeks
|
in both fetal and adult BM sources
|
in vivo
|
| 36983 |
HSC (CD150-CD45+CD201+CD48-)
|
|
increases_activity of
|
repopulation >16 weeks
|
in both fetal and adult BM sources
|
in vivo
|
|
19377048
|
|
1,971
|
| 16668 |
HSCalpha (CD45(mid)lin-Rho-SP)
|
|
increases_activity of
|
repopulation >16 weeks
|
myeloid-biased
|
in vivo
|
| 16669 |
HSCbeta (CD45(mid)lin-Rho-SP)
|
|
increases_activity of
|
repopulation >16 weeks
|
myeloid- and lymphoid-biased
|
in vivo
|
| 16670 |
HSCgamma (CD45(mid)lin-Rho-SP)
|
|
increases_activity of
|
repopulation >16 weeks
|
myeloid- and lymphoid-biased
|
in vivo
|
| 16672 |
HSCdelta (CD45(mid)lin-Rho-SP)
|
|
increases_activity of
|
repopulation >16 weeks
|
lymphoid-biased
|
in vivo
|
|
18371352
|
|
1,995
|
| 15724 |
My-bi-HSC (lower SP,KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
compared to upper-SP-KSl population
|
in vivo
|
| 15725 |
Ly-bi-HSC (upper SP,KSL)
|
|
decreases_activity of
|
repopulation >16 weeks
|
compared to lower-SP-KSl population
|
in vivo
|
|
20207229
|
|
2,059
|
| 16465 |
Hoxb4
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Hoxb4 is overexpressed
|
in vivo
|
| 16466 |
Smarcc1
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Smarcc1 is overexpressed
|
in vivo
|
| 16467 |
Vps72
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Vps72 is overexpressed
|
in vivo
|
| 16468 |
Fos
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if FOS is overexpressed
|
in vivo
|
| 16469 |
Trim27
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Trim27 is overexpressed
|
in vivo
|
| 16470 |
Sox4
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Sox4 is overexpressed
|
in vivo
|
| 16471 |
Klf10
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Klf10 is overexpressed
|
in vivo
|
| 16472 |
Ski
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Ski is overexpressed
|
in vivo
|
| 16473 |
Prdm16
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Prdm16 is overexpressed
|
in vivo
|
| 16474 |
Erdr1
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Erdr1 is overexpressed
|
in vivo
|
| 16475 |
Spi1
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Sfpi1 is overexpressed
|
in vivo
|
| 16602 |
Tfec
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Tcfec is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16605 |
Zfp472
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Zfp472 is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16607 |
Hmgb1
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Hmgb1 is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16608 |
Cnbp
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Cnbp is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16609 |
Pml
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Pml is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16610 |
Xbp1
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Xbp1 is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16611 |
Hnrnpdl
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Hnrbpl is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
| 16612 |
Hdac1
|
|
increases_activity of
|
repopulation >16 weeks
|
in HSC (CD150+CD48-Lin-); if Hdac1 is overexpressed, but with a lower activity than Hoxb4
|
in vivo
|
|
19379700
|
|
2,152
|
| 17947 |
HSC (Rho(lo)KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
12228721
|
|
2,157
|
| 17989 |
HSC (Lin-CD34+CD38-)
|
|
increases_activity of
|
repopulation >16 weeks
|
in NOD-SCID mice
|
|
|
12228721
|
|
2,197
|
| 18361 |
HSC (SP,KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
|
|
15459755
|
|
2,569
|
| 24166 |
HSC (CD34-CD135-Tie2+KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
|
| 24167 |
HSC (CD150+CD48-)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
|
| 24881 |
HSC (CD34-Mpl+KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
in comparison to HSC (Mpl-KSL) cells
|
in vivo
|
| 24882 |
HSC (CD34-Mpl-KSL)
|
|
decreases_activity of
|
repopulation >16 weeks
|
in comparison to HSC (Mpl+KSL) cells
|
in vivo
|
|
18371409
|
|
2,626
|
| 24950 |
Thpo
|
|
increases_activity of
|
repopulation >16 weeks
|
in KSL cells and FLT3-KSL HSCs
|
in vivo
|
|
18371408
|
|
2,627
|
| 24956 |
Mpl
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
9448308
|
|
2,628
|
| 24962 |
HSC (Tie2+SP,KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
compared to Tie2-cells
|
in vivo
|
| 25855 |
Tie2/Ang1 signaling
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
15260986
|
|
2,656
|
| 25051 |
Mpl
|
|
increases_activity of
|
repopulation >16 weeks
|
compared to WT or Mpl-/-Lnk-/- double knockouts
|
in vivo
|
| 25069 |
Sh2b3
|
|
decreases_activity of
|
repopulation >16 weeks
|
compared to WT or Mpl-/-Lnk-/- double knockouts; probably through downregulating JAK2 activation
|
in vivo
|
|
18618018
|
|
2,744
|
| 25415 |
Sh2b3
|
|
decreases_activity of
|
repopulation >16 weeks
|
in HSC (CD34-KSL); after TPO treatment
|
in vivo
|
|
17284614
|
|
2,766
|
| 25862 |
Cxcr4
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
| 30460 |
CXCL12/CXCR4 signaling
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
17174120
|
|
2,827
|
| 26383 |
HSC (endCD150+CD48-KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
| 26385 |
HSC (centCD150+CD48-KSL)
|
|
decreases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
20631378
|
|
2,856
|
| 26355 |
osteoblast-enriched cell (Alcam+Sca1-)
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (KSL) cells
|
in vitro
|
|
20472830
|
|
2,858
|
| 28792 |
Bmp4
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (KSL)
|
in vivo
|
|
19759357
|
|
2,862
|
| 26414 |
Ebf2
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
20887955
|
|
2,940
|
| 26843 |
Casr
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (KSL)
|
in vivo
|
|
16382241
|
|
2,944
|
| 26860 |
Vegfa
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (CD34-KSL) in hypoxic condition
|
|
| 26874 |
response to hypoxia
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (CD34-KSL) via hypoxia/HIF-driven Vegfa up-regulation
|
|
|
21670467
|
|
2,962
|
| 27004 |
HSC (Thy1(lo)Sca1+Lin-)
|
|
increases_activity of
|
repopulation >16 weeks
|
About 25% of mice competitively reconstiuted with Thy1lo)Sca1+Lin- cells exhibit long-term reconstitution for at least 4 month.
|
in vivo
|
|
1346154
|
|
2,965
|
| 27020 |
HSC (Kit+Lin-)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
1717068
|
|
2,967
|
| 27033 |
HSC (KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
1281687
|
|
2,968
|
| 27043 |
HSC (Thy1(lo)Sca+Lin-)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
7911343
|
|
2,986
|
| 27209 |
HSC (CD34-SP(Tip),KSL)
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
|
14738767
|
HSC