|
1,944
|
| 15223 |
Csf3
|
|
increases_activity of
|
cell cycle
|
of d-HSC (LRC) by inducing injury signals
|
in vivo
|
|
19062086
|
|
1,952
|
| 15117 |
dormant-HSC (LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
decreases_activity of
|
cell cycle
|
about 100% are in G0 phase
|
in vivo
|
| 40041 |
active-HSC (non-LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
increases_activity of
|
cell cycle
|
about 83% are in G0 phase
|
in vivo
|
|
19062086
|
|
1,995
|
| 15874 |
Cdkn2c
|
|
decreases_activity of
|
cell cycle
|
|
|
| 15875 |
Cdkn2d
|
|
decreases_activity of
|
cell cycle
|
|
|
| 16547 |
Tgfb1
|
|
increases_activity of
|
cell cycle
|
in My-HSC (lower SP-KSL), but not in Ly-HSC (upper SP-KSL)
|
in vitro
|
|
20207229
|
|
2,067
|
| 16652 |
Itch
|
|
decreases_activity of
|
cell cycle
|
|
in vitro
|
|
21478879
|
|
2,068
|
| 16653 |
Notch1
|
|
increases_activity of
|
cell cycle
|
if the intracellular domain of Notch1 is overexpressed
|
|
|
21478879
|
|
2,102
|
| 17162 |
Ccnd3
|
|
affects_activity of
|
cell cycle
|
|
|
| 17181 |
Ndn
|
|
affects_activity of
|
cell cycle
|
|
|
| 17183 |
Cenpe
|
|
affects_activity of
|
cell cycle
|
|
|
| 17184 |
Kif4
|
|
affects_activity of
|
cell cycle
|
|
|
| 17185 |
Kif22
|
|
affects_activity of
|
cell cycle
|
|
|
|
16151515
|
|
2,140
|
| 17719 |
HSC (CD34-CD135-CD150+CD48-KSL)
|
|
decreases_activity of
|
cell cycle
|
about 70% are in G0 phase
|
in vivo and in vitro
|
| 17720 |
MPP (CD34+CD48-CD150+CD135-KSL)
|
|
increases_activity of
|
cell cycle
|
compared to the CD34- population; about 40% are in G0 phase
|
in vivo and in vitro
|
| 17721 |
MPP (CD34+CD48+CD150-CD135+KSL)
|
|
increases_activity of
|
cell cycle
|
compared to the CD135- population; about 6% are in G0 phase
|
in vivo and in vitro
|
| 17722 |
dormant-HSC (LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
|
decreases_activity of
|
cell cycle
|
|
in vivo
|
|
19062086
|
|
2,150
|
| 17945 |
Meis1
|
|
affects_activity of
|
cell cycle
|
|
|
|
12228720
|
|
2,211
|
| 18570 |
Gadd45b
|
|
decreases_activity of
|
cell cycle
|
|
|
| 18571 |
Tob1
|
|
decreases_activity of
|
cell cycle
|
|
|
| 18572 |
Ccnb2
|
|
affects_activity of
|
cell cycle
|
|
|
| 24068 |
Btg3
|
|
decreases_activity of
|
cell cycle
|
|
|
|
15459755
|
|
2,566
|
| 24080 |
Cd48
|
|
increases_activity of
|
cell cycle
|
in HSC (SP,CD48+KSL); in comparison to HSC (SP, Sca1+CD48-)
|
in vitro
|
|
15459755
|
|
2,628
|
| 25029 |
Angpt1
|
|
decreases_activity of
|
cell cycle
|
in LT-HSC (Tie2+SP,KSL)
|
in vitro
|
|
15260986
|
|
2,744
|
| 25403 |
Sh2b3
|
|
decreases_activity of
|
cell cycle
|
in HSC (CD34-KSL); after TPO treatment
|
in vitro
|
|
17284614
|
|
2,834
|
| 26306 |
Dkk1
|
|
increases_activity of
|
cell cycle
|
of HSC (KSL)
|
in vivo
|
|
18371452
|
|
2,878
|
| 26518 |
Wif1
|
|
increases_activity of
|
cell cycle
|
in HSC (KSL); if Wif1 is overexpressed in osteoblasts
|
in vivo
|
|
21652676
|
|
2,895
|
| 26593 |
Spp1
|
|
decreases_activity of
|
cell cycle
|
of HSC (KSL)
|
in vivo
|
|
15845900
|
|
3,007
|
| 27407 |
Ccnd2
|
|
affects_activity of
|
cell cycle
|
|
|
| 27408 |
Ikzf1
|
|
affects_activity of
|
cell cycle
|
|
|
| 27409 |
Elf4
|
|
affects_activity of
|
cell cycle
|
|
|
|
17379664
|
|
3,022
|
| 27699 |
Zfp36
|
|
affects_activity of
|
cell cycle
|
|
|
|
12393558
|
|
3,106
|
| 28602 |
Cdkn2a
|
|
decreases_activity of
|
cell cycle
|
together with p53
|
in vitro
|
|
12714971
|
|
3,117
|
| 28647 |
Relb
|
|
decreases_activity of
|
cell cycle
|
in KSL cells of RelB/Nfkb double knockout mice
|
in vivo
|
| 28659 |
Nfkb2
|
|
decreases_activity of
|
cell cycle
|
in KSL cells of RelB/Nfkb double knockout mice
|
in vivo
|
| 28660 |
RelB/NF-kappaB signaling
|
|
decreases_activity of
|
cell cycle
|
in KSL cells of RelB/Nfkb double knockout mice
|
in vivo
|
|
22290873
|
|
3,125
|
| 28746 |
Nfya
|
|
increases_activity of
|
cell cycle
|
in BM progenitors and precursors. Quiescent HSCs do not depend on NF-Y activity.
|
in vivo
|
| 28758 |
Ccnb1
|
|
increases_activity of
|
cell cycle
|
|
|
|
22072554
|
|
3,132
|
| 28844 |
Myc
|
|
increases_activity of
|
cell cycle
|
in BM (Lin+) cells
|
in vivo
|
|
15545632
|
|
3,148
|
| 28981 |
Kit
|
|
decreases_activity of
|
cell cycle
|
in LT-HSC (CD34-Flk2-KSL)
|
|
|
18250409
|
|
3,150
|
| 29005 |
Cdkn1a
|
|
decreases_activity of
|
cell cycle
|
of BM (lin-) cells
|
in vivo
|
|
10710306
|
|
3,155
|
| 29034 |
Tgfb1
|
|
decreases_activity of
|
cell cycle
|
Inhibtion of the cell cycle is independent of p21 or p27
|
in vitro
|
|
11739168
|
|
3,184
|
| 29238 |
Flt1
|
|
increases_activity of
|
cell cycle
|
|
in vivo
|
|
12091880
|
|
3,186
|
| 29258 |
Ptk2
|
|
decreases_activity of
|
cell cycle
|
|
|
|
22155722
|
|
3,201
|
| 29411 |
Cdh2
|
|
decreases_activity of
|
cell cycle
|
of HSC (KSL) or HSC (SP,KSL)
|
in vitro
|
|
20207221
|
|
3,205
|
| 29503 |
Skp2
|
|
affects_activity of
|
cell cycle
|
by degradation of cell cycle inhibitors like p21 or p27
|
|
| 29504 |
Ubiquitin E3 ligase (SKP1A, SKP2, CUL1, RBX1)
|
|
affects_activity of
|
cell cycle
|
by degradation of cell cycle inhibitors like p21 or p27
|
|
| 29515 |
Skp2
|
|
decreases_activity of
|
cell cycle
|
in LT-HSC (CD34-Flk2-KSL)
|
in vivo
|
| 29538 |
Ccnd1
|
|
increases_activity of
|
cell cycle
|
in HSC (KSL) cells
|
in vitro
|
|
21931116
|
|
3,207
|
| 29550 |
Cdkn1c
|
|
decreases_activity of
|
cell cycle
|
|
|
| 29559 |
Skp2
|
|
increases_activity of
|
cell cycle
|
in HSC (KSL) cells; The percentage of cells in the early S-phase was not significantly altered, however percentage of cells in late S-phase was significantly reduced in Skp2-/- mice.
|
in vivo
|
| 29583 |
Rbl2
|
|
decreases_activity of
|
cell cycle
|
|
|
| 29584 |
Ccne1
|
|
increases_activity of
|
cell cycle
|
|
|
| 29586 |
Myc
|
|
increases_activity of
|
cell cycle
|
|
|
|
21502543
|
|
3,322
|
| 30530 |
Cxcr4
|
|
decreases_activity of
|
cell cycle
|
|
in vivo
|
| 30534 |
Cxcl12
|
|
decreases_activity of
|
cell cycle
|
|
in vitro
|
|
18378795
|
HSC