Lithium and its molecular targets

Lithium salts are being used in psychiatry to treat bipolar disorder. In recent years, evidence has accumulated that lithium also has a positive effect in other areas including cardio- and neuroprotective properties. The following Mg2+-dependent enzymes are known to be directly inhibited by lithium: inositol monophosphatase (IMPA1, IMPA2), inositol polyphosphate 1-phosphatase (INPP1), glycogen synthase kinase-3 (GSK3-beta and -alpha), fructose 1,6-bisphosphatase (FBP), bisphosphate nucleotidase (BPNT1) and phosphoglucomutase (PGM). In addition, lithium also affects the assembly of protein complexes such as AKT-ARRB2-PPP2CA complex or the assembly of the CREB1 cofactor CBP-CRTC1.

List all interactions Display Graph

Statistics

Interactions	152	Proteins/Genes	35	Chemical compounds/drugs	10
Biological Process(GO)	10	Phenotype	0

Proteins/Genes

GSK3B	18
AKT1	13
PGM	8
CREB1	7
Protein kinase C	7
KCNQ2	6
Adenylate cyclase	6
JUN	5
BPNT1	5
MAPK8	5
more...

Biological Process(GO)

glucose metabolic process	6
G protein-coupled receptor signaling pathway	4
autophagy	3
apoptotic process	3
histone H3-K27 methylation	2
epithelial to mesenchymal transition	2
ion transport	1
phosphatidylinositol-mediated signaling	1
calcium-mediated signaling	1
calcium ion import	1

Chemical compounds/drugs

Lithium	78
Inositol	7
Phosphatidylinositol-4,5-bisphosphate	5
Diacylglycerol	3
Inositol 1,4,5-trisphosphate	3
alpha-D-Glucose 1,6-bisphosphate	3
cAMP	3
Phosphatidylinositol-3,4,5-trisphosphate	2
Adenylate cyclase	1
AMP	1