Histone acetylation/deacetylation via HDACs alters chromosome structure and affects transcription factor access to DNA. HDACs are catalyzed by multisubunit complexes and play a key role in the regulation of eukaryotic gene expression.
mTOR signaling regulates a wide range of biological processes, including cell growth, various types of cellular differentiation, and metabolism. It assembles two biochemically and functionally distinct protein complexes:
mTORC1 (mTOR complex 1) and mTORC2 (mTOR complex 2).
The complex interaction network between mTOR and the various HDACs is shown in this graph.
CIDeRplus
List all interactions
Display Graph