|
97
|
| 317 |
SOD1-p.G93A
|
|
increases_quantity of
|
TNF
|
in adult microglia; LPS stimulated
|
| 318 |
SOD1-p.G93A
|
|
decreases_quantity of
|
IL6
|
in adult microglia; LPS stimulated
|
|
15378658
|
Amyotrophic lateral sclerosis
|
|
98
|
| 319 |
SOD1-p.G93A
|
|
increases_activity of
|
microglial cell activation
|
in microglia cultures
|
| 321 |
SOD1-p.G93A
|
|
increases_quantity of
|
TNF
|
in microglia cultures
|
| 323 |
SOD1-p.G93A
|
|
increases_quantity of
|
IL1B
|
in microglia cultures
|
| 324 |
SOD1-p.G93A
|
|
increases_expression of
|
CYBB
|
in microglia cultures
|
| 325 |
SOD1-p.G93A
|
|
increases_expression of
|
NOS2
|
in microglia cultures
|
| 326 |
SOD1-p.G93A
|
|
increases_quantity of
|
IGF1
|
in microglia cultures
|
| 329 |
SOD1-p.G93A
|
|
increases_quantity of
|
O2-
|
in microglia cultures
|
| 331 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
CD14
|
|
|
19672969
|
Amyotrophic lateral sclerosis
|
|
101
|
| 341 |
SOD1-p.G93A
|
|
increases_activity of
|
ERN1
|
in motor neurons
|
| 343 |
SOD1-p.G93A
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
in motor neurons
|
| 346 |
SOD1-p.G93A
|
|
increases_activity of
|
EIF2AK3
|
in motor neurons
|
| 347 |
SOD1-p.G93A
|
|
increases_activity of
|
MAP3K5
|
in motor neurons
|
| 353 |
SOD1-p.G93A
|
|
increases_quantity of
|
DDIT3
|
in motor neurons
|
| 356 |
SOD1-p.G93A
|
|
increases_quantity of
|
HSPA5
|
in motor neurons
|
| 363 |
SOD1-p.G93A
|
|
decreases_activity of
|
ER-associated ubiquitin-dependent protein catabolic process
|
in motor neurons
|
| 366 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
DERL1
|
in motor neurons
|
| 398 |
SOD1-p.G93A
|
|
increases_activity of
|
motor neuron degeneration
|
in motor neurons
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
106
|
| 370 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
DERL1
|
in liver
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
107
|
| 372 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
DERL1
|
in cerebral cortex
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
108
|
| 374 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
DERL1
|
in cerebellum
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
109
|
| 376 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
DERL1
|
in medulla
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
111
|
| 377 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
DERL1
|
in spinal cord
|
| 379 |
SOD1-p.G93A
|
|
is localized in
|
cytoplasm
|
mainly
|
| 381 |
SOD1-p.G93A
|
|
is localized in
|
endoplasmic reticulum membrane
|
partly
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
114
|
| 387 |
SOD1-p.G93A
|
NOT |
affects_quantity of
|
glia
|
|
| 390 |
SOD1-p.G93A
|
|
decreases_quantity of
|
motoneuron
|
|
| 85862 |
SOD1-p.G93A
|
|
increases_activity of
|
motor neuron degeneration
|
|
|
18519638
|
Amyotrophic lateral sclerosis
|
|
151
|
| 572 |
SOD1-p.G93A
|
|
increases_phosphorylation of
|
EIF2AK3
|
if mutant SOD1 is over-expressed
|
| 576 |
SOD1-p.G93A
|
|
increases_phosphorylation of
|
EIF2S1
|
if mutant SOD1 is over-expressed
|
| 585 |
SOD1-p.G93A
|
|
increases_phosphorylation of
|
MAPK8
|
if mutant SOD1 is over-expressed
|
| 601 |
SOD1-p.G93A
|
|
increases_transport of
|
ATF6
|
into nucleus; if mutant SOD1 is over-expressed
|
| 611 |
SOD1-p.G93A
|
|
increases_expression of
|
HSPA5
|
if mutant SOD1 is over-expressed
|
| 613 |
SOD1-p.G93A
|
|
decreases_expression of
|
BCL2
|
if mutant SOD1 is over-expressed
|
| 614 |
SOD1-p.G93A
|
|
increases_expression of
|
BAX
|
if mutant SOD1 is over-expressed
|
| 629 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP12
|
if mutant SOD1 is over-expressed
|
| 631 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP7
|
if mutant SOD1 is over-expressed
|
| 644 |
SOD1-p.G93A
|
|
increases_activity of
|
neuron apoptotic process
|
if mutant SOD1 is over-expressed
|
|
18233996
|
Amyotrophic lateral sclerosis
|
|
172
|
| 691 |
SOD1-p.G93A
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
in motoneurons; from stage P12 up to P26
|
| 696 |
SOD1-p.G93A
|
|
increases_expression of
|
EIF2A
|
in motoneurons; from stage P32 on
|
| 701 |
SOD1-p.G93A
|
|
increases_expression of
|
ATF4
|
in motoneurons; from stage P32 on
|
| 702 |
SOD1-p.G93A
|
|
increases_expression of
|
GADD45A
|
in motoneurons; from stage P32 on
|
| 703 |
SOD1-p.G93A
|
|
increases_expression of
|
ATF3
|
in motoneurons; from stage P32 on
|
| 704 |
SOD1-p.G93A
|
|
increases_expression of
|
LAPTM5
|
in motoneurons; from stage P32 on
|
| 707 |
SOD1-p.G93A
|
|
increases_expression of
|
GRN
|
in motoneurons; from stage P32 on
|
| 708 |
SOD1-p.G93A
|
|
increases_expression of
|
NRN1
|
in motoneurons; from stage P32 on
|
| 709 |
SOD1-p.G93A
|
|
increases_expression of
|
HEXB
|
in motoneurons; from stage P32 on
|
| 710 |
SOD1-p.G93A
|
|
increases_expression of
|
EIF2AK3
|
in motoneurons; from stage P32 on
|
| 711 |
SOD1-p.G93A
|
|
decreases_expression of
|
USP53
|
in motoneurons; from stage P32 on
|
| 712 |
SOD1-p.G93A
|
|
decreases_expression of
|
UCHL5
|
in motoneurons; from stage P32 on
|
| 713 |
SOD1-p.G93A
|
|
decreases_expression of
|
UBE2Q1
|
in motoneurons; from stage P32 on
|
| 716 |
SOD1-p.G93A
|
|
increases_expression of
|
IFIH1
|
in motoneurons; from stage P32 on
|
| 717 |
SOD1-p.G93A
|
|
increases_expression of
|
IFITM3
|
in motoneurons; from stage P32 on
|
| 718 |
SOD1-p.G93A
|
|
increases_expression of
|
C1QB
|
in motoneurons; from stage P32 on
|
| 737 |
SOD1-p.G93A
|
|
increases_expression of
|
HSPA5
|
in motoneurons; from stage P20 to P38
|
|
19330001
|
Amyotrophic lateral sclerosis
|
|
177
|
| 720 |
SOD1-p.G93A
|
|
increases_activity of
|
microglial cell activation
|
between stage P28 and P32
|
|
19330001
|
Amyotrophic lateral sclerosis
|
|
196
|
| 780 |
SOD1-p.G93A
|
|
increases_activity of
|
motor neuron degeneration
|
|
| 784 |
SOD1-p.G93A
|
|
increases_activity of
|
response to endoplasmic reticulum stress
|
|
| 786 |
SOD1-p.G93A
|
|
increases_quantity of
|
HSPA5
|
|
| 788 |
SOD1-p.G93A
|
|
increases_quantity of
|
HSP90B1
|
|
| 789 |
SOD1-p.G93A
|
|
increases_quantity of
|
Ubiquitin
|
|
| 793 |
SOD1-p.G93A
|
|
increases_expression of
|
DDIT3
|
|
| 794 |
SOD1-p.G93A
|
|
increases_expression of
|
BCL2L11
|
|
| 795 |
SOD1-p.G93A
|
|
increases_expression of
|
BBC3
|
|
| 13274 |
SOD1-p.G93A
|
|
increases_quantity of
|
DDIT3
|
|
| 13275 |
SOD1-p.G93A
|
|
increases_quantity of
|
BCL2L11
|
|
| 13276 |
SOD1-p.G93A
|
|
increases_quantity of
|
BBC3
|
|
|
18077368
|
Amyotrophic lateral sclerosis
|
|
218
|
| 875 |
SOD1-p.G93A
|
|
increases_quantity of
|
P4HB
|
|
| 876 |
SOD1-p.G93A
|
|
increases_quantity of
|
PDIA3
|
|
| 888 |
SOD1-p.G93A
|
|
interacts (colocalizes) with
|
P4HB
|
|
| 890 |
SOD1-p.G93A
|
|
increases_quantity of
|
EIF2AK3
|
at stage p90 and disease end stage p120
|
| 891 |
SOD1-p.G93A
|
|
increases_quantity of
|
ATF6
|
at stage p90 and disease end stage p120
|
| 892 |
SOD1-p.G93A
|
|
increases_quantity of
|
DDIT3
|
at stage p90 and disease end stage p120
|
| 893 |
SOD1-p.G93A
|
|
increases_quantity of
|
ERN1
|
at stage p90 and disease end stage p120
|
| 894 |
SOD1-p.G93A
|
|
increases_quantity of
|
HSPA5
|
at disease end stage p120
|
| 895 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP12
|
at stage p90 and disease end stage p120
|
| 896 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP9
|
at disease end stage p120
|
| 897 |
SOD1-p.G93A
|
|
increases_activity of
|
CASP3
|
at disease end stage p120
|
|
16847061
|
Amyotrophic lateral sclerosis
|
|
222
|
| 13337 |
AMFR
|
|
increases_ubiquitination/sumoylation of
|
SOD1-p.G93A
|
|
| 13338 |
AMFR
|
|
interacts (colocalizes) with
|
SOD1-p.G93A
|
|
| 13339 |
AMFR
|
|
decreases_quantity of
|
SOD1-p.G93A
|
|
|
19661182
|
Amyotrophic lateral sclerosis
|
|
238
|
| 986 |
SOD1-p.G93A
|
|
increases_quantity of
|
AMFR
|
|
| 13348 |
SOD1-p.G93A
|
|
increases_quantity of
|
SOD1 protein aggregates
|
|
|
19661182
|
Amyotrophic lateral sclerosis
|
|
293
|
| 1172 |
SOD1-p.G93A
|
NOT |
affects_expression of
|
ANG
|
|
| 1175 |
SOD1-p.G93A
|
|
decreases_expression of
|
VEGFA
|
|
| 1179 |
SOD1-p.G93A
|
|
decreases_expression of
|
KDR
|
|
|
19444281
|
Amyotrophic lateral sclerosis
|
|
310
|
| 13452 |
SOD1-p.G93A
|
|
increases_activity of
|
p38 MAPK
|
|
|
16581901
|
Amyotrophic lateral sclerosis
|
|
373
|
| 1526 |
SOD1-p.G93A
|
|
increases_activity of
|
neuron apoptotic process
|
|
|
16000635
|
Amyotrophic lateral sclerosis
|
|
377
|
| 1534 |
SOD1-p.G93A
|
|
increases_quantity of
|
p38 MAPK
|
in spinal cord
|
| 1536 |
SOD1-p.G93A
|
|
increases_activity of
|
p38 MAPK
|
in spinal cord
|
| 13499 |
SOD1-p.G93A
|
NOT |
increases_expression of
|
p38 MAPK
|
in spinal cord
|
|
12812752
|
Amyotrophic lateral sclerosis
|
|
379
|
| 1555 |
SOD1-p.G93A
|
|
increases_quantity of
|
TNF
|
in SOD1(G93A) transgenic mice
|
|
17630988
|
Amyotrophic lateral sclerosis
|
|
385
|
| 1578 |
SOD1-p.G93A
|
|
increases_quantity of
|
TNF
|
in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
|
| 1582 |
SOD1-p.G93A
|
|
decreases_quantity of
|
IL6
|
in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
|
| 1583 |
SOD1-p.G93A
|
NOT |
increases_expression of
|
TNF
|
in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
|
| 1586 |
SOD1-p.G93A
|
|
increases_quantity of
|
H2O2
|
in TLR2 or TLR4 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
|
| 1592 |
SOD1-p.G93A
|
|
increases_activity of
|
response to oxidative stress
|
in TLR2 or TLR4 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
|
| 1607 |
SOD1-p.G93A
|
NOT |
affects_quantity of
|
IL1B
|
in TLR2 stimulated murine microglial cell line BV-2; if mutSOD1 is overexpressed
|
|
19091752
|
Amyotrophic lateral sclerosis
|
|
391
|
| 1608 |
SOD1-p.G93A
|
|
increases_quantity of
|
TNF
|
in spinal cord motor neurons; especially at stage 90-110 days
|
| 1613 |
SOD1-p.G93A
|
|
increases_quantity of
|
FASLG
|
in spinal cord motor neurons; as early as 60 days
|
| 1621 |
SOD1-p.G93A
|
|
increases_activity of
|
motor neuron degeneration
|
in spinal cord motor neurons
|
| 1626 |
SOD1-p.G93A
|
|
increases_expression of
|
TNF
|
in spinal cord motor neurons
|
| 1672 |
SOD1-p.G93A
|
|
increases_expression of
|
IL1A
|
in spinal cord; at 110 days of age
|
| 1685 |
SOD1-p.G93A
|
|
increases_expression of
|
IL1B
|
in spinal cord; at 110 days of age
|
| 1688 |
SOD1-p.G93A
|
|
increases_expression of
|
IL12B
|
in spinal cord; at 110 days of age
|
| 1691 |
SOD1-p.G93A
|
|
increases_expression of
|
IL1RN
|
in spinal cord; at 110 days of age
|
| 1695 |
SOD1-p.G93A
|
NOT |
affects_expression of
|
TGFB1
|
in spinal cord; at 110 days of age
|
|
16510725
|
Amyotrophic lateral sclerosis
|
|
396
|
| 1638 |
SOD1-p.G93A
|
|
increases_quantity of
|
TNF
|
in astrocytes; at 110 days of age
|
| 1648 |
SOD1-p.G93A
|
|
increases_quantity of
|
FASLG
|
in astrocytes; as early as 60 days
|
|
16510725
|
Amyotrophic lateral sclerosis
|
|
404
|
| 1724 |
SOD1-p.G93A
|
|
increases_expression of
|
P2RX7
|
in immortalized microglia
|
| 1727 |
SOD1-p.G93A
|
|
increases_expression of
|
P2RY6
|
in immortalized microglia
|
| 1728 |
SOD1-p.G93A
|
|
decreases_activity of
|
nucleotidase activity
|
in immortalized microglia
|
| 1732 |
SOD1-p.G93A
|
|
increases_expression of
|
TNF
|
in immortalized microglia
|
| 1733 |
SOD1-p.G93A
|
NOT |
affects_expression of
|
IL1B
|
in immortalized microglia
|
| 1735 |
SOD1-p.G93A
|
|
increases_quantity of
|
PTGS2
|
in immortalized microglia
|
| 1767 |
SOD1-p.G93A
|
|
increases_activity of
|
microglial cell activation
|
in SOD1G93A transgenic mice
|
| 1768 |
SOD1-p.G93A
|
|
increases_activity of
|
motor neuron degeneration
|
in SOD1G93A transgenic mice
|
| 13503 |
SOD1-p.G93A
|
NOT |
increases_expression of
|
P2RX4
|
in immortalized and primary microglia
|
| 13506 |
SOD1-p.G93A
|
NOT |
increases_expression of
|
P2RY2
|
in immortalized and primary microglia
|
| 13508 |
SOD1-p.G93A
|
NOT |
increases_expression of
|
P2RY12
|
in immortalized and primary microglia
|
| 13509 |
SOD1-p.G93A
|
|
increases_quantity of
|
P2RX4
|
in immortalized and primary microglia
|
| 13510 |
SOD1-p.G93A
|
|
increases_quantity of
|
P2RX7
|
in immortalized and primary microglia
|
| 13520 |
SOD1-p.G93A
|
|
affects_activity of
|
purinergic receptor signaling pathway
|
in immortalized and primary microglia
|
|
19734218
|
Amyotrophic lateral sclerosis
|
|
417
|
| 1829 |
SOD1-p.G93A
|
|
increases_quantity of
|
O2-
|
if SOD1G93A is overexpressed
|
| 1832 |
SOD1-p.G93A
|
|
affects_activity of
|
RAC1
|
if SOD1G93A is overexpressed
|
|
18219391
|
Amyotrophic lateral sclerosis
|
|
420
|
| 1833 |
SOD1-p.G93A
|
|
increases_quantity of
|
O2-
|
in brain, spinal cord and liver; if SOD1G93A is overexpressed
|
|
18219391
|
Amyotrophic lateral sclerosis
|
|
422
|
| 1836 |
SOD1-p.G93A
|
|
increases_quantity of
|
O2-
|
if SOD1G93A is overexpressed
|
| 1842 |
SOD1-p.G93A
|
|
affects_activity of
|
RAC1
|
if SOD1G93A is overexpressed
|
|
18219391
|
Amyotrophic lateral sclerosis
|
|
423
|
| 1846 |
SOD1-p.G93A
|
|
increases_quantity of
|
O2-
|
if SOD1G93A is overexpressed
|
|
18219391
|
Amyotrophic lateral sclerosis
|
|
450
|
| 1996 |
CCS
|
|
increases_quantity of
|
SOD1-p.G93A
|
in mitochondria; if CCS is overexpressed
|
|
17389365
|
Amyotrophic lateral sclerosis
|
CIDeRplus