|
9
|
| 24 |
IL1B
|
|
decreases_expression of
|
SIRT1
|
|
| 40 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
|
| 42 |
SIRT1
|
|
decreases_expression of
|
NOS2
|
if SIRT1 is overexpressed
|
|
19008341
|
Diabetes mellitus, type I
|
|
12
|
| 43 |
IL1B
|
|
decreases_expression of
|
SIRT1
|
|
| 45 |
SIRT1
|
|
decreases_expression of
|
NOS2
|
if SIRT1 is overexpressed
|
| 46 |
SIRT1
|
|
increases_activity of
|
insulin secretion
|
if SIRT1 is overexpressed in cytokine treated cells
|
|
19008341
|
Diabetes mellitus, type I
|
|
39
|
| 90 |
SIRT1
|
|
interacts (colocalizes) with
|
RELA
|
|
| 91 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
|
| 93 |
SIRT1
|
|
decreases_activity of
|
positive regulation of NF-kappaB transcription factor activity
|
|
| 95 |
SIRT1
|
|
decreases_activity of
|
EP300
|
if SIRT1 is overexpressed
|
| 96 |
SIRT1
|
|
decreases_acetylation of
|
RELA
|
|
|
15152190
|
Diabetes mellitus, type I
|
|
824
|
| 4790 |
SIRT1
|
|
decreases_acetylation of
|
PPARGC1A
|
|
| 4791 |
SIRT1
|
|
increases_activity of
|
PPARGC1A
|
|
| 4816 |
SIRT1
|
|
decreases_acetylation of
|
PPARGC1B
|
|
| 4817 |
SIRT1
|
|
increases_activity of
|
PPARGC1B
|
|
| 4818 |
SIRT1
|
|
is localized in
|
nucleus
|
|
| 4869 |
SIRT1
|
|
increases_activity of
|
PPARGC1A
|
in skeletal muscle
|
| 4905 |
SIRT1
|
|
decreases_acetylation of
|
CRTC2
|
|
| 4906 |
SIRT1
|
|
decreases_quantity of
|
CRTC2
|
via ubiquitin-mediated degradation of CRTC2
|
| 4907 |
SIRT1
|
|
decreases_activity of
|
gluconeogenesis
|
|
| 4908 |
Glucagon
|
NOT |
affects_activity of
|
SIRT1
|
|
| 4917 |
SIRT1
|
|
increases_activity of
|
improved glucose tolerance
|
in pancreas, in pancreatic islets
|
| 4918 |
SIRT1
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
| 4919 |
SIRT1
|
|
decreases_expression of
|
UCP2
|
in pancreas, in pancreatic islets
|
| 4920 |
SIRT1
|
|
decreases_expression of
|
PRLR
|
in pancreas, in pancreatic islets
|
| 4951 |
SIRT1
|
|
decreases_acetylation of
|
NR1H
|
|
| 4952 |
SIRT1
|
|
increases_activity of
|
NR1H
|
|
| 5076 |
SIRT1
|
|
interacts (colocalizes) with
|
PPARG
|
in adipose tissue, in mature adipocytes
|
| 5078 |
SIRT1
|
|
decreases_activity of
|
PPARG
|
in adipose tissue, in mature adipocytes
|
| 5080 |
SIRT1
|
|
increases_activity of
|
fat reserve metabolic process
|
in adipose tissue, in mature adipocytes; during food deprivation
|
| 5136 |
SRT1720
|
|
increases_activity of
|
SIRT1
|
|
|
19770177
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
868
|
| 5146 |
SIRT1
|
NOT |
affects_quantity of
|
Insulin
|
in blood; on standard diet, if SIRT1 is overexpressed
|
| 5148 |
SIRT1
|
NOT |
affects_quantity of
|
Glucose
|
in blood; on standard diet, if SIRT1 is overexpressed
|
| 5149 |
SIRT1
|
NOT |
affects_activity of
|
response to glucose
|
on standard diet, if SIRT1 is overexpressed
|
| 5181 |
SIRT1
|
NOT |
affects_activity of
|
response to insulin
|
on standard diet, if SIRT1 is overexpressed
|
| 5182 |
SIRT1
|
|
increases_quantity of
|
ADIPOQ
|
in blood; on standard diet, if SIRT1 is overexpressed
|
| 5184 |
SIRT1
|
|
affects_activity of
|
increased basal metabolism
|
on standard diet, if SIRT1 is overexpressed
|
| 5185 |
SIRT1
|
|
decreases_activity of
|
Insulin resistance
|
if SIRT1 is overexpressed
|
| 5186 |
SIRT1
|
NOT |
affects_activity of
|
increased basal metabolism
|
on high-fat diet, if SIRT1 is overexpressed
|
| 5187 |
SIRT1
|
|
decreases_quantity of
|
Insulin
|
in blood; on high-fat diet, if SIRT1 is overexpressed
|
| 5188 |
SIRT1
|
|
increases_quantity of
|
ADIPOQ
|
in blood; on high-fat diet, if SIRT1 is overexpressed
|
| 5189 |
SIRT1
|
NOT |
affects_quantity of
|
RETN
|
in blood; on high-fat diet, if SIRT1 is overexpressed
|
| 5190 |
SIRT1
|
NOT |
affects_quantity of
|
SERPINE1
|
in blood; on high-fat diet, if SIRT1 is overexpressed
|
| 5191 |
SIRT1
|
NOT |
affects_quantity of
|
TNF
|
in blood; on high-fat diet, if SIRT1 is overexpressed
|
| 5193 |
SIRT1
|
NOT |
affects_quantity of
|
LEP
|
in blood; on high-fat diet, if SIRT1 is overexpressed
|
| 5194 |
SIRT1
|
|
increases_expression of
|
ADIPOQ
|
in white adipose tissue; on standard diet, on high-fat diet, if SIRT1 is overexpressed
|
| 5197 |
SIRT1
|
|
increases_activity of
|
AMPK
|
in white adipose tissue, in liver, in skeletal muscle; on high-fat diet, if SIRT1 is overexpressed
|
| 5199 |
SIRT1
|
|
increases_expression of
|
PPARA
|
in liver; on high-fat diet, if SIRT1 is overexpressed
|
| 5201 |
SIRT1
|
|
increases_expression of
|
CPT1A
|
in liver; on high-fat diet, via increased PPAR-alpha expression, if SIRT1 is overexpressed
|
| 5202 |
SIRT1
|
|
increases_expression of
|
ADIPOR2
|
in liver; on high-fat diet, via increased PPAR-alpha expression, if SIRT1 is overexpressed
|
| 5205 |
SIRT1
|
|
decreases_acetylation of
|
FOXO1
|
|
| 5207 |
SIRT1
|
|
decreases_acetylation of
|
FOXO1
|
in liver; if SIRT1 is overexpressed
|
| 5208 |
SIRT1
|
|
decreases_acetylation of
|
PPARGC1A
|
in skeletal muscle; if SIRT1 is overexpressed
|
| 13148 |
SIRT1
|
NOT |
affects_activity of
|
abnormal body weight
|
on standard diet, if SIRT1 is overexpressed
|
|
18840364
|
Diabetes mellitus, type II
Insulin resistance
|
|
897
|
| 5302 |
SRT1720
|
|
interacts (colocalizes) with
|
SIRT1
|
|
| 5311 |
SRT1720
|
|
increases_activity of
|
SIRT1
|
|
| 5314 |
SIRT1
|
|
decreases_activity of
|
increased circulating insulin level
|
in diet-induced obesity mice
|
| 5317 |
SIRT1
|
NOT |
affects_quantity of
|
Insulin
|
in non-insulin resistant chow-fed mice
|
| 5318 |
SIRT1
|
|
increases_activity of
|
CS
|
in gastrocnemius muscle
|
| 5320 |
SIRT1
|
|
decreases_quantity of
|
Glucose
|
in blood; in diabetic Lep ob/ob mice
|
| 5331 |
SIRT1
|
|
decreases_activity of
|
Insulin resistance
|
in adipose tissue, in skeletal muscle, in liver; in Zucker fa/fa rats
|
| 50433 |
SRT501
|
|
increases_activity of
|
SIRT1
|
|
|
18046409
|
Diabetes mellitus, type II
Insulin resistance
|
|
904
|
| 5370 |
SIRT1
|
NOT |
affects_activity of
|
abnormal body weight
|
if SIRT1 is overexpressed
|
| 5373 |
SIRT1
|
NOT |
affects_quantity of
|
LEP
|
in blood; on standard diet, on high-fat diet, if SIRT1 is overexpressed
|
| 5374 |
SIRT1
|
NOT |
affects_quantity of
|
ADIPOQ
|
in blood; on standard diet, on high-fat diet, if SIRT1 is overexpressed
|
| 5375 |
SIRT1
|
|
affects_activity of
|
increased food intake
|
on high-fat diet, if SIRT1 is overexpressed
|
| 5376 |
SIRT1
|
|
affects_activity of
|
increased energy expenditure
|
on high-fat diet, if SIRT1 is overexpressed
|
| 5379 |
SIRT1
|
NOT |
affects_activity of
|
energy homeostasis
|
on high-fat diet, if SIRT1 is overexpressed
|
| 5381 |
SIRT1
|
|
affects_activity of
|
Fatty liver disease, nonalcoholic
|
after 19 weeks of high-fat diet, if SIRT1 is overexpressed
|
| 5382 |
SIRT1
|
|
affects_expression of
|
SREBF1c
|
in response to high-fat diet, if SIRT1 is overexpressed
|
| 5383 |
SIRT1
|
|
decreases_activity of
|
Fatty liver disease, nonalcoholic
|
|
| 5388 |
SIRT1
|
NOT |
affects_expression of
|
IL6
|
in liver; in response to high-fat diet, if SIRT1 is overexpressed
|
| 5389 |
SIRT1
|
NOT |
affects_expression of
|
TNF
|
in liver; in response to high-fat diet, if SIRT1 is overexpressed
|
| 5394 |
SIRT1
|
|
affects_activity of
|
NF-kappaB complex
|
if SIRT1 is overexpressed
|
| 5396 |
SIRT1
|
|
affects_expression of
|
SOD2
|
on standard diet, on high-fat diet, if SIRT1 is overexpressed
|
| 5399 |
SIRT1
|
|
decreases_activity of
|
inflammatory response
|
if SIRT1 is overexpressed, via decreased NF-kappaB activity
|
| 13187 |
SIRT1
|
NOT |
affects_activity of
|
increased energy expenditure
|
on standard diet, if SIRT1 is overexpressed
|
| 13191 |
SIRT1
|
|
affects_expression of
|
NRF1
|
on standard diet, on high-fat diet, if SIRT1 is overexpressed
|
| 13192 |
SIRT1
|
|
increases_activity of
|
PPARGC1A
|
on standard diet, on high-fat diet, if SIRT1 is overexpressed
|
| 13193 |
SIRT1
|
|
decreases_activity of
|
response to oxidative stress
|
if SIRT1 is overexpressed
|
|
18599449
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
906
|
| 5402 |
SirT1 ASO rat
|
|
decreases_expression of
|
SIRT1
|
in liver, in white adipose tissue, in brown adipose tissue
|
| 5426 |
SirT1 ASO rat
|
NOT |
decreases_expression of
|
SIRT1
|
in muscle
|
| 5427 |
SirT1 ASO rat
|
NOT |
decreases_expression of
|
SIRT1
|
in hypothalamus
|
| 5428 |
SIRT1
|
|
affects_quantity of
|
Fatty acid
|
in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5433 |
SIRT1
|
|
affects_quantity of
|
LEP
|
in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5436 |
SIRT1
|
|
affects_quantity of
|
ADIPOQ
|
in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5438 |
SIRT1
|
|
affects_expression of
|
PPARG
|
in epididymal white adipose tissue; both splice variants PPAR-gamma1 and PPAR-gamma2, if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5443 |
SIRT1
|
|
affects_quantity of
|
CEBPA
|
in adipose tissue; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5445 |
SIRT1
|
NOT |
affects_quantity of
|
Triacylglycerol
|
in blood, in liver; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5446 |
SIRT1
|
|
affects_quantity of
|
(R)-3-Hydroxybutanoate
|
in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5449 |
SIRT1
|
|
affects_quantity of
|
Cholesterol
|
in blood; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5452 |
SIRT1
|
|
affects_expression of
|
NR1H3
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5454 |
SIRT1
|
|
affects_expression of
|
SCARB1
|
if SIRT1 is knocked down in liver and white adipose tissue of diabetic rats
|
| 5457 |
SIRT1
|
|
affects_expression of
|
CYP7A1
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5458 |
SIRT1
|
|
affects_activity of
|
bile acid biosynthetic process
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5460 |
SIRT1
|
|
affects_expression of
|
LDLR
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5462 |
SIRT1
|
NOT |
affects_expression of
|
ABCG8
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5463 |
SIRT1
|
NOT |
affects_expression of
|
SREBF2
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5465 |
SIRT1
|
NOT |
affects_expression of
|
HMGCR
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5469 |
SIRT1
|
|
affects_activity of
|
increased insulin sensitivity
|
in liver; if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5472 |
SIRT1
|
|
affects_acetylation of
|
STAT3
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5475 |
SIRT1
|
|
affects_phosphorylation of
|
STAT3
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5478 |
SIRT1
|
|
affects_acetylation of
|
FOXO1
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5480 |
SIRT1
|
|
affects_acetylation of
|
PPARGC1A
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5481 |
SIRT1
|
|
affects_expression of
|
PCK1
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5482 |
SIRT1
|
|
affects_expression of
|
FBP1
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5484 |
SIRT1
|
|
affects_expression of
|
G6PC
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
| 5486 |
SIRT1
|
|
affects_activity of
|
gluconeogenesis
|
if SIRT1 is knocked down in liver and adipose tissue of diabetic rats
|
|
19549853
|
Diabetes mellitus, type II
Insulin resistance
|
|
918
|
| 5660 |
prolonged fasting
|
|
increases_quantity of
|
SIRT1
|
in liver
|
| 5662 |
SIRT1
|
|
decreases_acetylation of
|
CRTC2
|
during prolonged fasting
|
| 5667 |
SIRT1
|
|
decreases_quantity of
|
CRTC2
|
via ubiquitin-dependent degradation by COP1 during prolonged fasting
|
| 5669 |
SIRT1
|
|
increases_activity of
|
FOXO1
|
during prolonged fasting
|
| 5673 |
SIRT1
|
|
affects_activity of
|
CRTC2
|
|
| 5727 |
SIRT1
|
|
affects_quantity of
|
Glucose
|
|
| 5728 |
SIRT1
|
|
decreases_activity of
|
CRTC2
|
|
|
18849969
|
Diabetes mellitus, type II
Insulin resistance
|
|
947
|
| 5731 |
SIRT1
|
|
affects_activity of
|
peroxisome proliferator activated receptor alpha signaling pathway
|
in liver; if SIRT1 is knocked out in liver
|
| 5742 |
SIRT1
|
|
affects_expression of
|
ACADM
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5746 |
SIRT1
|
|
affects_expression of
|
EHHADH
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5747 |
SIRT1
|
|
affects_expression of
|
ACOX1
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5754 |
SIRT1
|
|
affects_expression of
|
CD36
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5755 |
SIRT1
|
|
affects_expression of
|
Cyp4A10
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5756 |
SIRT1
|
|
affects_expression of
|
Cyp4A14
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5758 |
SIRT1
|
|
affects_expression of
|
THRSP
|
in liver; on chow diet, if SIRT1 is knocked out in liver
|
| 5759 |
SIRT1
|
|
affects_expression of
|
CPT1A
|
in liver; after overnight fasting, if SIRT1 is knocked out in liver
|
| 5763 |
SIRT1
|
|
affects_expression of
|
ACOX1
|
in liver; after overnight fasting, if SIRT1 is knocked out in liver
|
| 5764 |
SIRT1
|
|
affects_expression of
|
CD36
|
in liver; after overnight fasting, if SIRT1 is knocked out in liver
|
| 5765 |
SIRT1
|
|
affects_expression of
|
Cyp4A14
|
in liver; after overnight fasting, if SIRT1 is knocked out in liver
|
| 5766 |
SIRT1
|
|
affects_expression of
|
CYCS
|
in liver; after overnight fasting, if SIRT1 is knocked out in liver
|
| 5768 |
SIRT1
|
|
affects_expression of
|
PPARGC1A
|
in liver; after overnight fasting, if SIRT1 is knocked out in liver
|
| 5777 |
SIRT1
|
|
affects_activity of
|
regulation of peroxisome proliferator activated receptor signaling pathway
|
in liver
|
| 5780 |
SIRT1
|
|
increases_activity of
|
PPARA
|
|
| 5787 |
SIRT1
|
|
interacts (colocalizes) with
|
PPARA
|
|
| 5788 |
SIRT1
|
|
increases_activity of
|
PPARGC1A
|
|
| 5793 |
SIRT1
|
|
affects_activity of
|
Obesity
|
if SIRT1 is knocked out in liver
|
| 5796 |
SIRT1
|
|
affects_expression of
|
CPT1A
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5804 |
SIRT1
|
|
affects_expression of
|
CPT2
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5805 |
SIRT1
|
|
affects_expression of
|
ACAD
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5806 |
SIRT1
|
|
decreases_expression of
|
ACOX1
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5807 |
SIRT1
|
|
affects_expression of
|
CD36
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5808 |
SIRT1
|
|
affects_expression of
|
Cyp4A14
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5809 |
SIRT1
|
|
affects_expression of
|
Cyp4A10
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5811 |
SIRT1
|
|
affects_activity of
|
fatty acid beta-oxidation
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5820 |
SIRT1
|
|
affects_expression of
|
CYCS
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5821 |
SIRT1
|
|
affects_expression of
|
COX4
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5843 |
SIRT1
|
|
affects_expression of
|
COX5B
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5849 |
SIRT1
|
|
affects_activity of
|
oxidative phosphorylation
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5850 |
SIRT1
|
|
affects_expression of
|
PPARGC1A
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5851 |
SIRT1
|
|
affects_expression of
|
GPAM
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5852 |
SIRT1
|
|
affects_expression of
|
DGAT1
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5853 |
SIRT1
|
|
affects_expression of
|
DGAT2
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5854 |
SIRT1
|
|
affects_activity of
|
triglyceride biosynthetic process
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5855 |
SIRT1
|
|
affects_activity of
|
CYP7A1
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5857 |
SIRT1
|
|
affects_activity of
|
liver inflammation
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5858 |
SIRT1
|
|
affects_activity of
|
response to endoplasmic reticulum stress
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 5862 |
SIRT1
|
|
affects_quantity of
|
EIF2S1-phos
|
in liver; if SIRT1 is knocked out in liver
|
| 5876 |
SIRT1
|
|
affects_quantity of
|
JUN-phos
|
in liver; if SIRT1 is knocked out in liver
|
| 5884 |
SIRT1
|
|
affects_quantity of
|
CCL3
|
in liver; if SIRT1 is knocked out in liver
|
| 5885 |
SIRT1
|
|
affects_quantity of
|
VCAM1
|
in liver; if SIRT1 is knocked out in liver
|
| 5887 |
SIRT1
|
|
affects_quantity of
|
SAA1
|
in liver; if SIRT1 is knocked out in liver
|
| 5888 |
SIRT1
|
|
affects_quantity of
|
CXCL10
|
in liver; if SIRT1 is knocked out in liver
|
| 5889 |
SIRT1
|
|
affects_quantity of
|
TNF
|
in liver; if SIRT1 is knocked out in liver
|
| 5890 |
SIRT1
|
|
affects_quantity of
|
IL1B
|
in liver; if SIRT1 is knocked out in liver
|
| 5891 |
SIRT1
|
|
affects_quantity of
|
AKT1-phosSer473
|
in liver; on high-fat diet, if SIRT1 is knocked out in liver
|
| 13195 |
SIRT1
|
|
affects_activity of
|
fatty acid beta-oxidation
|
in liver; via PPARA
|
| 13196 |
SIRT1
|
|
affects_quantity of
|
Lipid
|
in liver; if SIRT1 is knocked out in liver
|
| 13197 |
SIRT1
|
|
affects_quantity of
|
Fatty acid
|
in blood; if SIRT1 is knocked out in liver
|
| 13198 |
SIRT1
|
|
affects_quantity of
|
(R)-3-Hydroxybutanoate
|
in blood; if SIRT1 is knocked out in liver
|
|
19356714
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
1,007
|
| 6284 |
Alzheimer disease
|
|
decreases_expression of
|
SIRT1
|
in the parietal cortex of AD patients, but not in the cerebellum
|
| 29672 |
mild cognitive impairment
|
NOT |
decreases_expression of
|
SIRT1
|
in the cortex of AD patients
|
|
19104446
|
Alzheimer disease
|
|
1,023
|
| 6377 |
SIRT1
|
|
decreases_quantity of
|
amyloid beta deposits
|
in rat primary neuronal culture; (microglia-dependent amyloid beta toxicity)
|
| 6418 |
SIRT1
|
|
decreases_activity of
|
NF-kappaB signaling
|
|
| 6420 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
|
| 106868 |
SIRT1
|
|
decreases_activity of
|
NF-kappaB complex
|
in rat primary neuronal culture; (microglia-dependent amyloid beta toxicity)
|
|
16183991
|
Alzheimer disease
|
|
1,179
|
| 13352 |
NOS2
|
|
affects_expression of
|
SIRT1
|
|
|
20532036
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,759
|
| 13222 |
SIRT1
|
|
affects_activity of
|
NEUROG2
|
during murine embryonic caudal neural tube development at E9.5, but not at E12.5
|
|
21169561
|
Neurological
|
|
2,006
|
| 15911 |
SIRT1
|
|
decreases_activity of
|
amyloidosis
|
in cell culture studies in vitro and in transgenic mouse models of Alzheimer's disease
|
| 15914 |
SIRT1
|
|
increases_activity of
|
ADAM10
|
|
|
21349442
|
Alzheimer disease
|
|
2,007
|
| 15918 |
response to stress
|
|
affects_expression of
|
SIRT1
|
|
| 15922 |
phosphorylation
|
|
affects_activity of
|
SIRT1
|
|
| 15924 |
SIRT1
|
|
decreases_acetylation of
|
HSF1
|
if SIRT1 is phosphorylated.
|
| 15927 |
SIRT1
|
|
increases_activity of
|
HSF1
|
if SIRT1 is phosphorylated.
|
| 15942 |
SIRT1
|
|
affects_activity of
|
Deacetylase
|
|
| 15943 |
SIRT1
|
|
increases_expression of
|
Alpha-secretase
|
|
|
21121893
|
Alzheimer disease
|
|
2,008
|
| 15946 |
calorie restriction
|
|
increases_expression of
|
SIRT1
|
in the brain; of about 10-month-old Tg2576 mice
|
| 15970 |
SIRT1
|
|
increases_activity of
|
Alpha-secretase
|
|
| 15971 |
SIRT1
|
|
decreases_quantity of
|
Amyloid beta peptide
|
|
|
16751189
|
Alzheimer disease
|
|
4,000
|
| 41068 |
Obesity
|
|
decreases_expression of
|
SIRT1
|
in subcutaneous adipose tissue; in monozygotic twins discordant for obesity
|
|
18336063
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
4,348
|
| 44453 |
Rotenone
|
|
increases_expression of
|
SIRT1
|
at concentrations of 12.5 and 25 nmol/L rotenone
|
|
23930106
|
Diabetes mellitus, type II
Insulin resistance
|
|
4,370
|
| 44566 |
Melatonin
|
|
increases_expression of
|
SIRT1
|
|
|
19650880
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,061
|
| 49769 |
mir-128-2
|
|
decreases_quantity of
|
SIRT1
|
|
|
23990020
|
Metabolic
Cardiovascular disease
|
|
5,152
|
| 50404 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
in kidney; in db/db mice
|
|
23090186
|
Diabetes mellitus, type II
Insulin resistance
Nephropathy, diabetic
|
|
5,241
|
| 51091 |
SIRT1
|
|
increases_activity of
|
PPARGC1A
|
via deacetylation
|
| 51096 |
NAD+
|
|
increases_activity of
|
SIRT1
|
|
| 51097 |
SIRT1
|
|
affects_activity of
|
lipid catabolic process
|
in white adipose tissue
|
| 51098 |
SIRT1
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic beta cells
|
| 51099 |
SIRT1
|
|
affects_activity of
|
ACSS1
|
|
| 51101 |
SIRT1
|
|
affects_activity of
|
ACSS2
|
|
| 51102 |
SIRT1
|
|
affects_activity of
|
circadian rhythm
|
|
| 51104 |
SIRT1
|
|
affects_activity of
|
response to heat
|
|
| 51105 |
SIRT1
|
|
affects_activity of
|
cellular response to DNA damage stimulus
|
|
| 51107 |
SIRT1
|
|
affects_activity of
|
response to hypoxia
|
|
| 51108 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
|
| 51115 |
SIRT1
|
|
increases_expression of
|
PCK1
|
via PPARGC1A
|
| 51118 |
SIRT1
|
|
increases_expression of
|
G6PC
|
via PPARGC1A
|
| 51121 |
feeding
|
|
affects_quantity of
|
SIRT1
|
|
|
20005308
|
Diabetes mellitus, type II
Insulin resistance
|
|
5,291
|
| 51752 |
SIRT1
|
|
increases_expression of
|
PPARGC1A
|
in skeletal muscle
|
|
19553684
|
Diabetes mellitus, type II
Insulin resistance
|
|
6,212
|
| 58878 |
spermatogonial stem cell
|
|
decreases_expression of
|
SIRT1
|
in both differentiating and aging spermatogonial stem cells
|
| 58881 |
Rapamycin
|
|
increases_expression of
|
SIRT1
|
in both differentiating and aging spermatogonial stem cells (SSCs)
|
|
22729928
|
Metabolic
|
|
6,301
|
| 60069 |
Panobinostat
|
|
decreases_activity of
|
SIRT1
|
|
| 60088 |
Peripheral T-cell leukemia / lymphoma
|
|
increases_expression of
|
SIRT1
|
Pattern of staining: Nuclear.
|
| 60119 |
SIRT1
|
|
decreases_acetylation of
|
AKT1
|
|
| 60139 |
SIRT1
|
|
increases_activity of
|
AKT1
|
via promoting phosphatidylinositol (3,4,5)-triphosphate binding to Akt.
|
| 60156 |
Vorinostat
|
|
decreases_activity of
|
SIRT1
|
of SIRT1 mRNA and Sirt1 deacetylase activity.
|
| 60191 |
Angioimmunoblastic T-Cell lymphoma
|
|
increases_expression of
|
SIRT1
|
|
|
25674239
|
Cancer
Cutaneous T-cell lymphoma
Peripheral T-cell leukemia / lymphoma
Angioimmunoblastic T-Cell lymphoma
|
|
6,302
|
| 60205 |
Tris(2-chloroethyl)phosphate
|
|
increases_expression of
|
SIRT1
|
in L02 and HepG2 cells; upregulated mRNA and protein levels of SIRT1
|
| 60209 |
SIRT1
|
NOT |
affects_activity of
|
PI3K/AKT/TOR signaling
|
in L02 and HepG2 cells
|
| 60210 |
EX-527
|
|
decreases_activity of
|
SIRT1
|
in L02 and HepG2 cells
|
| 60211 |
SIRT1
|
|
increases_activity of
|
PTEN/PI3K/AKT signaling
|
if SIRT1 is overexpressed, resulting in a protection of the cells from apoptosis.
|
| 60212 |
SIRT1
|
|
decreases_activity of
|
TOR signaling
|
in mouse embryonic fibroblasts and HeLa cells; if SIRT1 is overexpressed, via TSC1-TSC2 complex.
|
| 60213 |
SIRT1
|
|
decreases_activity of
|
cell population proliferation
|
in vitro and tumor formation in colon cancer
|
| 60219 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
resulting in an inhibition of cell growth by inducing cell cycle arrest.
|
| 60350 |
SIRT1
|
|
increases_activity of
|
mitotic entry
|
of liver cells; if SIRT1 is overexpressed.
|
| 60351 |
SIRT1
|
|
increases_activity of
|
cell growth
|
if SIRT1 is overexpressed.
|
| 60352 |
SIRT1
|
|
increases_activity of
|
cell population proliferation
|
if SIRT1 is overexpressed.
|
| 60353 |
SIRT1
|
|
decreases_activity of
|
apoptotic process
|
if SIRT1 is overexpressed through activation of the PTEN/PI3K/Akt pathway.
|
| 60354 |
SIRT1
|
|
affects_activity of
|
TSC1-TSC2 complex
|
in mouse embryonic fibroblasts and HeLa cells; if SIRT1 is overexpressed, resulting in a negative regulation the mTOR pathway.
|
| 60357 |
SIRT1
|
|
decreases_activity of
|
cell growth
|
by inducing cell cycle arrest.
|
| 60358 |
SIRT1
|
|
increases_activity of
|
cell cycle arrest
|
|
| 60359 |
SIRT1
|
|
decreases_activity of
|
Breast cancer
|
reducing tumor formation in a breast cancer model.
|
| 136232 |
Tris(2-chloroethyl)phosphate
|
|
increases_quantity of
|
SIRT1
|
in L02 and HepG2 cells; upregulated mRNA and protein levels of SIRT1
|
|
26378621
|
Breast cancer
|
|
6,303
|
| 59024 |
caloric restriction diet
|
|
increases_activity of
|
SIRT1
|
concerning mRNA expression.
|
|
26135885
|
Metabolic
|
|
6,387
|
| 61567 |
SIRT1
|
|
is localized in
|
nucleus
|
|
| 61617 |
NAD+
|
|
affects_activity of
|
SIRT1
|
|
| 61621 |
SIRT1
|
|
interacts (colocalizes) with
|
CLOCK-BMAL1 complex
|
|
| 61624 |
exercise
|
|
increases_activity of
|
SIRT1
|
|
| 61625 |
fasting
|
|
increases_activity of
|
SIRT1
|
|
| 61626 |
caloric restriction
|
|
increases_activity of
|
SIRT1
|
|
| 61630 |
SIRT1
|
|
affects_activity of
|
circadian clock
|
|
| 61631 |
SIRT1
|
|
increases_quantity of
|
O-Acetyl-ADP-ribose
|
|
| 61632 |
SIRT1
|
|
increases_quantity of
|
Nicotinamide
|
|
| 61635 |
SIRT1
|
|
affects_activity of
|
TP53
|
|
| 61641 |
SIRT1
|
|
affects_activity of
|
PPARGC1A
|
|
| 61642 |
SIRT1
|
|
affects_activity of
|
HIF1A
|
|
| 61643 |
SIRT1
|
|
affects_activity of
|
EPAS1
|
|
| 61644 |
SIRT1
|
|
affects_activity of
|
NR1H
|
|
| 61645 |
SIRT1
|
|
affects_activity of
|
GPR85
|
|
| 61646 |
SIRT1
|
|
affects_activity of
|
NR1H4
|
|
| 61647 |
SIRT1
|
|
affects_activity of
|
NFKB1
|
|
| 61648 |
SIRT1
|
|
affects_activity of
|
PER2
|
|
| 61649 |
SIRT1
|
|
affects_activity of
|
CRTC2
|
|
| 61650 |
SIRT1
|
|
affects_activity of
|
E2F1
|
|
| 61651 |
SIRT1
|
|
affects_activity of
|
XRCC6
|
|
| 61652 |
Resveratrol
|
|
increases_activity of
|
SIRT1
|
depending on a functional AMPK
|
| 61653 |
Hydroxytyrosol
|
|
increases_expression of
|
SIRT1
|
|
| 61654 |
SIRT1
|
|
interacts (colocalizes) with
|
FOXO
|
|
| 61655 |
SIRT1
|
|
decreases_acetylation of
|
FOXO
|
|
| 61656 |
SIRT1
|
|
decreases_acetylation of
|
ATG5
|
|
| 61657 |
SIRT1
|
|
decreases_acetylation of
|
ATG7
|
|
| 61658 |
SIRT1
|
|
decreases_acetylation of
|
GABARAPL
|
|
| 61674 |
AMPK
|
|
affects_activity of
|
SIRT1
|
via modifying the NAD+/NADH ratio
|
| 61676 |
SIRT1
|
|
affects_activity of
|
STK11
|
|
| 61677 |
SIRT1
|
|
decreases_quantity of
|
MTOR
|
if SIRT1 is overexpressed
|
| 61679 |
SIRT1
|
|
decreases_activity of
|
MTOR
|
if SIRT1 is overexpressed
|
| 61680 |
SIRT1
|
|
decreases_activity of
|
TOR signaling
|
if SIRT1 is overexpressed
|
|
25955819
|
Metabolic
|
|
6,456
|
| 61184 |
SIRT1
|
|
decreases_activity of
|
CRTC2
|
via deacetylation
|
| 61187 |
Metformin
|
|
increases_activity of
|
SIRT1
|
|
|
22117616
|
Diabetes mellitus, type II
Cancer
Insulin resistance
|
CIDeRplus