10
|
28 |
LRRK2
|
NOT |
increases_activity of
|
neuron death
|
|
30 |
LRRK2-p.R1441C
|
|
increases_activity of
|
neuron death
|
|
31 |
LRRK2-p.Y1699C
|
|
increases_activity of
|
neuron death
|
|
32 |
LRRK2-p.G2019S
|
|
increases_activity of
|
neuron death
|
|
|
16352719
|
Parkinson disease
|
11
|
33 |
LRRK2
|
NOT |
increases_activity of
|
neuron death
|
|
34 |
LRRK2-p.R1441C
|
|
increases_activity of
|
neuron death
|
|
35 |
LRRK2-p.Y1699C
|
|
increases_activity of
|
neuron death
|
|
36 |
LRRK2-p.G2019S
|
|
increases_activity of
|
neuron death
|
|
|
16352719
|
Parkinson disease
|
62
|
192 |
SNCA-p.A30P
|
|
increases_activity of
|
neuron death
|
in substantia nigra
|
1008 |
PRKN
|
|
decreases_activity of
|
neuron death
|
in substantia nigra
|
|
15576511
|
Parkinson disease 2, autosomal recessive juvenile
Parkinson disease
|
119
|
5017 |
XBP1
|
|
increases_activity of
|
neuron death
|
|
|
19762508
|
Amyotrophic lateral sclerosis
|
143
|
519 |
VAPB-p.P56S
|
|
increases_activity of
|
neuron death
|
|
|
19183264
|
Amyotrophic lateral sclerosis
|
156
|
2624 |
PINK1
|
|
affects_activity of
|
neuron death
|
|
2626 |
PRKN
|
|
decreases_activity of
|
neuron death
|
if cell death has been induced by loss of PINK1
|
|
19279012
|
Parkinson disease
|
202
|
802 |
EPO
|
|
decreases_activity of
|
neuron death
|
|
803 |
VEGFA
|
|
decreases_activity of
|
neuron death
|
|
804 |
TNFRSF1A
|
|
decreases_activity of
|
neuron death
|
|
809 |
Kainic acid
|
|
increases_activity of
|
neuron death
|
|
|
18413601
|
Amyotrophic lateral sclerosis
|
215
|
2860 |
MEF2D
|
|
affects_activity of
|
neuron death
|
|
|
19119233
|
Parkinson disease
|
268
|
1099 |
LRRK2-p.R1441C
|
|
increases_activity of
|
neuron death
|
|
1100 |
LRRK2-p.G2019S
|
|
increases_activity of
|
neuron death
|
|
1102 |
STUB1
|
|
decreases_activity of
|
neuron death
|
incuced by LRRK2 mutants
|
3751 |
17AAD
|
|
decreases_activity of
|
neuron death
|
induced by LRRK2 mutants
|
|
19196961
|
Parkinson disease
|
309
|
1223 |
LRRK2-p.G2019S
|
|
increases_activity of
|
neuron death
|
|
|
16980962
|
Neurological
|
310
|
1232 |
NO
|
|
increases_activity of
|
neuron death
|
in SOD1(G93A) or SOD1(G85R) mutant mice motoneurons
|
|
16581901
|
Amyotrophic lateral sclerosis
|
340
|
1385 |
LRRK2-FADD-CASP8 complex
|
|
increases_activity of
|
neuron death
|
|
|
19176810
|
Parkinson disease
|
352
|
1394 |
CASP8
|
|
increases_activity of
|
neuron death
|
|
|
11264300
|
Parkinson disease
|
353
|
1401 |
Caspase 8 inhibitor
|
NOT |
decreases_activity of
|
neuron death
|
|
|
11264300
|
Parkinson disease
|
357
|
1420 |
XENP345
|
|
decreases_activity of
|
neuron death
|
|
1421 |
TNF
|
|
increases_activity of
|
neuron death
|
|
1422 |
tumor necrosis factor-mediated signaling pathway
|
|
increases_activity of
|
neuron death
|
|
|
16971520
|
Parkinson disease
|
398
|
1700 |
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
|
|
increases_activity of
|
neuron death
|
|
|
6823561
|
Parkinson disease
|
413
|
1817 |
LRRK2-p.Y1699C
|
|
increases_activity of
|
neuron death
|
|
1818 |
LRRK2-p.R1441C
|
|
increases_activity of
|
neuron death
|
|
|
16750377
|
Parkinson disease
|
448
|
1981 |
LRRK2
|
|
affects_activity of
|
neuron death
|
|
1986 |
LRRK2-mut
|
|
increases_activity of
|
neuron death
|
|
|
18701920
|
Parkinson disease
|
466
|
2113 |
EIF4EBP1
|
|
decreases_activity of
|
neuron death
|
if 4E-BP is overexpressed in parkin mutant
|
2116 |
EIF4EBP1
|
|
decreases_activity of
|
neuron death
|
if 4E-BP is overexpressed in Pink1 mutant
|
2124 |
Rapamycin
|
|
decreases_activity of
|
neuron death
|
|
4007 |
PRKN
|
|
decreases_activity of
|
neuron death
|
|
4008 |
EIF4EBP1
|
|
decreases_activity of
|
neuron death
|
in Thor and park double mutants
|
|
19684592
|
Parkinson disease
|
467
|
2130 |
response to oxidative stress
|
|
increases_activity of
|
neuron death
|
|
|
18675914
|
Parkinson disease
|
475
|
2215 |
U0126
|
|
decreases_activity of
|
neuron death
|
if cell death has been induced by MPP
|
2217 |
MAP1LC3A
|
|
affects_activity of
|
neuron death
|
if cell death has been induced by MPP
|
2218 |
ATG5
|
|
affects_activity of
|
neuron death
|
if cell death has been induced by MPP
|
2219 |
ATG7
|
|
affects_activity of
|
neuron death
|
if cell death has been induced by MPP
|
|
17200184
|
Parkinson disease
|
482
|
2271 |
Dopamine
|
|
increases_activity of
|
neuron death
|
|
2272 |
Ascorbate
|
|
decreases_activity of
|
neuron death
|
|
2273 |
Acetylcysteine
|
|
decreases_activity of
|
neuron death
|
|
|
12868068
|
Parkinson disease
|
495
|
2376 |
PINK1
|
|
decreases_activity of
|
neuron death
|
|
2379 |
PINK1-p.G309D
|
|
increases_activity of
|
neuron death
|
|
2380 |
PINK1-p.L347P
|
|
increases_activity of
|
neuron death
|
|
|
17579517
|
Parkinson disease
|
515
|
2549 |
Rotenone
|
|
increases_activity of
|
neuron death
|
|
2550 |
Rapamycin
|
|
decreases_activity of
|
neuron death
|
if cell death has been induced by rotenone
|
2552 |
autophagy
|
|
decreases_activity of
|
neuron death
|
|
|
19682553
|
Neurological
|
518
|
2661 |
Rotenone
|
|
increases_activity of
|
neuron death
|
|
2664 |
PINK1
|
|
decreases_activity of
|
neuron death
|
if cell death has been induced by rotenone
|
|
19492085
|
Parkinson disease
|
547
|
13801 |
EPO
|
|
decreases_activity of
|
neuron death
|
in pilocarpine model
|
|
18479396
|
Status epilepticus
|
555
|
2893 |
Glutamate
|
|
increases_activity of
|
neuron death
|
in cortical neurons
|
2894 |
5-Hydroxy-1,4-naphthoquinone
|
|
decreases_activity of
|
neuron death
|
in cortical neurons; exposed to glutamate
|
2895 |
PIN1
|
|
increases_activity of
|
neuron death
|
in cortical neurons; exposed to glutamate
|
|
17626162
|
Amyotrophic lateral sclerosis
|
579
|
3056 |
magnesium ion homeostasis
|
|
increases_activity of
|
neuron death
|
|
|
18289526
|
Status epilepticus
|
672
|
3594 |
Status epilepticus
|
|
affects_activity of
|
neuron death
|
in lithium-pilocarpine model
|
3730 |
response to oxidative stress
|
|
affects_activity of
|
neuron death
|
in lithium-pilocarpine model
|
|
20149694
|
Status epilepticus
|
679
|
3650 |
LRRK2
|
|
increases_activity of
|
neuron death
|
|
3652 |
LRRK2-p.G2385R
|
|
increases_activity of
|
neuron death
|
|
3653 |
LRRK2-p.Y1699C
|
|
increases_activity of
|
neuron death
|
with a higher rate than wild type LRRK2
|
3654 |
LRRK2-p.G2019S
|
|
increases_activity of
|
neuron death
|
with a higher rate than wild type LRRK2
|
3655 |
LRRK2-p.I2020T
|
|
increases_activity of
|
neuron death
|
with a higher rate than wild type LRRK2
|
|
17200152
|
Parkinson disease
|