|
12
|
| 46 |
SIRT1
|
|
increases_activity of
|
insulin secretion
|
if SIRT1 is overexpressed in cytokine treated cells
|
| 48 |
Resveratrol
|
|
increases_activity of
|
insulin secretion
|
in cytokine treated cells
|
| 61 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in rat islets
|
|
19008341
|
Diabetes mellitus, type I
|
|
67
|
| 210 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in pancreatic islets
|
| 211 |
Sulforaphane
|
|
increases_activity of
|
insulin secretion
|
in pancreatic islets; in cytokine treated cells
|
|
19071154
|
Diabetes mellitus, type I
|
|
76
|
| 239 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in pancreatic islets
|
| 240 |
Troglitazone
|
|
increases_activity of
|
insulin secretion
|
in pancreatic islets; in cytokine treated cells
|
| 242 |
Ciglitazone
|
|
increases_activity of
|
insulin secretion
|
in pancreatic islets; in cytokine treated cells
|
|
17521952
|
Diabetes mellitus, type I
|
|
824
|
| 4918 |
SIRT1
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
|
19770177
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,409
|
| 10048 |
Anakinra
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
|
17429083
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,414
|
| 9742 |
ADIPOQ
|
NOT |
affects_activity of
|
insulin secretion
|
|
|
12829646
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,492
|
| 10535 |
hyperglycemia
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
| 10536 |
increased leptin level
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
|
18263705
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,504
|
| 10652 |
IL1B
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
| 10654 |
Pioglitazone
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; if IL1B or glucose is increased
|
| 10655 |
Sodium salicylate
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; if IL1B or glucose is increased
|
|
15472206
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,977
|
| 15493 |
Valsartan
|
|
increases_activity of
|
insulin secretion
|
after glucose stimulation
|
|
21330640
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,985
|
| 15586 |
Enalaprilat
|
NOT |
affects_activity of
|
insulin secretion
|
in pancreas
|
|
9498644
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,988
|
| 15622 |
hyperglycemia
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
| 15627 |
Enalaprilat
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
| 15629 |
Zofenopril
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
|
16452552
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,989
|
| 15638 |
impaired glucose tolerance
|
|
affects_activity of
|
insulin secretion
|
in pancreas; in early and late phase
|
| 15640 |
hyperglycemia
|
|
affects_activity of
|
insulin secretion
|
in pancreas; after fasting, in early phase, not in late phase
|
| 15692 |
Angiotensin II type 1 receptor blocker
|
|
decreases_activity of
|
insulin secretion
|
|
|
20809236
|
Diabetes mellitus, type II
Stroke, ischemic
Myocardial infarction
Insulin resistance
Cardiovascular disease
Nephropathy, diabetic
Retinopathy, diabetic
Neuropathy, diabetic
|
|
1,999
|
| 15792 |
Valsartan
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; after high-fat diet, after insulin stimulation
|
|
20100990
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,001
|
| 15854 |
Candesartan
|
|
increases_activity of
|
insulin secretion
|
|
|
16650382
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,046
|
| 16370 |
Valsartan
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; in db/db mice
|
| 16371 |
Exenatide
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; in db/db mice
|
|
18787107
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,272
|
| 19406 |
NNT
|
|
affects_activity of
|
insulin secretion
|
in pancreas
|
|
16399503
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,273
|
| 19412 |
NNT-p.N68K
|
|
affects_activity of
|
insulin secretion
|
in pancreas; in response to glucose
|
| 19415 |
NNT-p.G745D
|
|
affects_activity of
|
insulin secretion
|
in pancreas; in response to glucose
|
|
16399503
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,276
|
| 19430 |
NNT-truncated
|
NOT |
affects_activity of
|
insulin secretion
|
in pancreas
|
|
19906813
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,416
|
| 21742 |
DGKB-TMEM195 rs2191349
|
|
decreases_activity of
|
insulin secretion
|
the effective allele is T
|
| 21743 |
ADRA2A rs10885122
|
|
decreases_activity of
|
insulin secretion
|
the effective allele is G
|
| 21744 |
C2CD4B rs11071657
|
|
decreases_activity of
|
insulin secretion
|
the effective allele is A
|
| 21745 |
GLIS3 rs7034200
|
|
decreases_activity of
|
insulin secretion
|
the effective allele is A
|
|
20419449
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,417
|
| 21747 |
GLIS3 rs7034200
|
|
decreases_activity of
|
insulin secretion
|
in Han Chinese
|
| 21752 |
MADD rs7944584
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21757 |
ADRA2A rs10885122
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21762 |
CRY2 rs11605924
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21767 |
PROX1 rs340874
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21772 |
C2CD4B rs11071657
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21777 |
IGF1 rs35767
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21782 |
IRS1 rs2943641
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
| 21787 |
FADS1 rs174550
|
NOT |
affects_activity of
|
insulin secretion
|
in Han Chinese
|
|
21747906
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,451
|
| 22690 |
TCF7L2
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets
|
|
19386626
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,458
|
| 22766 |
KCNJ11 rs5219
|
|
decreases_activity of
|
insulin secretion
|
the risk allele is T
|
|
15111507
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,459
|
| 22771 |
CDKAL1 rs7756992
|
|
decreases_activity of
|
insulin secretion
|
|
|
17460697
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,466
|
| 22800 |
MTNR1B rs10830963
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; in Europeans, the risk allele is G
|
| 22803 |
Melatonin
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets, in beta cells
|
|
19060908
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,467
|
| 22815 |
KCNQ1 rs2237892
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; in Japanese, in Koreans, in Chinese, in Europeans, the risk allele is C
|
|
18711367
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,469
|
| 22831 |
GIPR rs10423928
|
|
decreases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; the effective allele is A
|
| 72842 |
GIPR
|
|
increases_activity of
|
insulin secretion
|
in pancreas, in pancreatic islets; the effective allele is A
|
|
20081857
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,493
|
| 23237 |
TCF7L2 rs7903146
|
|
affects_activity of
|
insulin secretion
|
the effective allele is T
|
| 23238 |
SLC30A8 rs13266634
|
|
affects_activity of
|
insulin secretion
|
the effective allele is C
|
| 23239 |
GIPR rs10423928
|
|
affects_activity of
|
insulin secretion
|
the effective allele is A
|
| 23240 |
C2CD4B rs11071657
|
|
affects_activity of
|
insulin secretion
|
the effective allele is A
|
|
20185807
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,497
|
| 23285 |
PROX1 rs340874
|
|
decreases_activity of
|
insulin secretion
|
in Han Chinese, the effective allele is C
|
| 23288 |
IGF1 rs35767
|
|
decreases_activity of
|
insulin secretion
|
in Han Chinese
|
|
21103350
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,501
|
| 23298 |
SLC30A8
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic beta cells; after glucose stimulation
|
|
16984975
|
Diabetes mellitus, type II
Insulin resistance
|
|
2,503
|
| 23323 |
SLC30A8
|
|
affects_activity of
|
insulin secretion
|
in pancreas, in pancreatic beta cells
|
|
20508080
|
Diabetes mellitus, type II
Insulin resistance
|
CIDeRplus