|
904
|
| 5399 |
SIRT1
|
|
decreases_activity of
|
inflammatory response
|
if SIRT1 is overexpressed, via decreased NF-kappaB activity
|
|
18599449
|
Diabetes mellitus, type II
Insulin resistance
Fatty liver disease, nonalcoholic
|
|
908
|
| 5423 |
Reactive oxygen species
|
|
increases_activity of
|
inflammatory response
|
in astrocytes; if ROS production is Abeta-induced
|
| 5514 |
Resveratrol
|
|
decreases_activity of
|
inflammatory response
|
|
| 5551 |
Curcumin
|
|
decreases_activity of
|
inflammatory response
|
|
|
19191039
|
Alzheimer disease
|
|
985
|
| 6135 |
Allium sativum (garlic) supplementation
|
|
decreases_activity of
|
inflammatory response
|
|
| 6136 |
S-allyl-cysteine
|
|
decreases_activity of
|
inflammatory response
|
|
| 6137 |
Di-allyl-disulfide
|
|
decreases_activity of
|
inflammatory response
|
|
|
16842945
|
Alzheimer disease
|
|
1,057
|
| 6606 |
PS cDKO mouse
|
|
increases_activity of
|
inflammatory response
|
in neocortex and hippocampus
|
|
15345711
|
Alzheimer disease
|
|
1,071
|
| 7461 |
PROC-mut
|
|
decreases_activity of
|
inflammatory response
|
in lumbar spinal cord
|
|
19841542
|
Amyotrophic lateral sclerosis
|
|
1,086
|
| 6884 |
Lipopolysaccharide
|
|
increases_activity of
|
inflammatory response
|
in astrocytes
|
| 6930 |
PARK7
|
|
affects_activity of
|
inflammatory response
|
in astrocytes; via p38MAPK pathway
|
| 6936 |
PTGS2
|
|
affects_activity of
|
inflammatory response
|
via Prostaglandin production
|
| 6937 |
inflammatory response
|
|
increases_activity of
|
Parkinson disease
|
|
| 8543 |
astrocyte activation
|
|
increases_activity of
|
inflammatory response
|
|
|
19276172
|
Parkinson disease
|
|
1,092
|
| 6985 |
inflammatory response
|
|
increases_activity of
|
SOCS1
|
|
| 6999 |
inflammatory response
|
|
increases_activity of
|
SOCS3
|
|
| 7067 |
inflammatory response
|
|
increases_activity of
|
increased circulating C-reactive protein level
|
|
| 7069 |
RETN
|
|
affects_activity of
|
inflammatory response
|
|
| 7071 |
LEP
|
|
affects_activity of
|
inflammatory response
|
|
| 7073 |
ADIPOQ
|
|
affects_activity of
|
inflammatory response
|
|
| 7083 |
increased circulating free fatty acid level
|
|
increases_activity of
|
inflammatory response
|
in vascular endothelial cells, in adipose tissue, in myeloid-derived cells
|
| 7274 |
NF-kappaB complex
|
|
increases_activity of
|
inflammatory response
|
|
| 7276 |
IL10
|
|
decreases_activity of
|
inflammatory response
|
|
| 7291 |
recruited adipose tissue macrophage
|
|
increases_activity of
|
inflammatory response
|
in adipose tissue
|
| 7302 |
M1 macrophage
|
|
increases_activity of
|
inflammatory response
|
|
| 7304 |
SORBS1
|
|
increases_activity of
|
inflammatory response
|
if inflammatory response is obesity-related
|
| 7317 |
PPARG
|
|
decreases_activity of
|
inflammatory response
|
in macrophages
|
| 7319 |
MAPK8
|
|
affects_activity of
|
inflammatory response
|
in macrophages
|
| 13444 |
resident adipose tissue macrophage
|
|
decreases_activity of
|
inflammatory response
|
in adipose tissue
|
| 45979 |
M2 macrophage
|
NOT |
increases_activity of
|
inflammatory response
|
|
| 45984 |
M1 macrophage
|
|
increases_activity of
|
inflammatory response
|
|
|
18053812
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,102
|
| 6995 |
Alzheimer disease
|
|
increases_activity of
|
inflammatory response
|
in PBMCs from AD patients compared to PBMCs in healthy controls
|
|
20462385
|
Alzheimer disease
|
|
1,107
|
| 7080 |
amyloid beta deposits
|
|
affects_activity of
|
inflammatory response
|
in AD brain
|
| 7094 |
inflammatory response
|
|
increases_activity of
|
microglia
|
concerning local or systemic inflammation
|
| 145268 |
neurofibrillary tangles
|
|
affects_activity of
|
inflammatory response
|
in AD brain
|
|
20462385
|
Alzheimer disease
Dementia
|
|
1,108
|
| 7112 |
convulsive seizures
|
|
increases_activity of
|
inflammatory response
|
|
|
1709015
|
Epilepsy
|
|
1,111
|
| 7125 |
inflammatory response
|
|
affects_activity of
|
TGFB1
|
in brain
|
|
11329064
|
Alzheimer disease
|
|
1,112
|
| 7184 |
transgenic hAPP/TGFbeta1 mouse
|
|
increases_activity of
|
inflammatory response
|
in transgenic hAPP/TGF-beta1 mice
|
|
11329064
|
Alzheimer disease
|
|
1,114
|
| 7203 |
TNF
|
|
increases_activity of
|
inflammatory response
|
|
|
18439917
|
Cardiovascular disease
|
|
1,116
|
| 8546 |
leukocyte migration involved in inflammatory response
|
|
increases_activity of
|
inflammatory response
|
|
|
20098715
|
Parkinson disease
|
|
1,119
|
| 7180 |
CFH
|
|
decreases_activity of
|
inflammatory response
|
|
|
18801740
|
Alzheimer disease
|
|
1,123
|
| 7217 |
inflammatory response
|
|
increases_expression of
|
NR4A2
|
in macrophages
|
| 7231 |
Lipopolysaccharide
|
|
increases_activity of
|
inflammatory response
|
|
|
19345186
|
Parkinson disease
|
|
1,124
|
| 7236 |
SNCA-p.A30P
|
|
increases_activity of
|
inflammatory response
|
in substantia nigra
|
| 7237 |
NR4A2
|
|
decreases_activity of
|
inflammatory response
|
in substantia nigra; via recruiting the CoREST-CtBP complex
|
| 7246 |
Lipopolysaccharide
|
|
increases_activity of
|
inflammatory response
|
primarily in microglia cells
|
| 7253 |
RELA
|
|
affects_activity of
|
inflammatory response
|
via NF-kappaB signaling
|
|
19345186
|
Parkinson disease
|
|
1,126
|
| 7310 |
SNCA-p.A53T
|
|
increases_activity of
|
inflammatory response
|
in striatum, but not in substantia nigra
|
|
19295143
|
Parkinson disease
|
|
1,145
|
| 7459 |
SNCA
|
|
increases_activity of
|
inflammatory response
|
|
| 7464 |
SNCA-p.A30P
|
|
increases_activity of
|
inflammatory response
|
more efficiently than wildtype SNCA
|
| 7465 |
SNCA-p.E46K
|
|
increases_activity of
|
inflammatory response
|
more efficiently than wildtype SNCA
|
| 7466 |
SNCA-p.A53T
|
|
increases_activity of
|
inflammatory response
|
more efficiently than wildtype SNCA
|
|
17166628
|
Parkinson disease
|
|
1,147
|
| 7486 |
inflammatory response
|
|
increases_quantity of
|
CRP
|
|
|
10591334
|
Diabetes mellitus, type II
Obesity
Insulin resistance
|
|
1,154
|
| 8245 |
CD14
|
|
affects_activity of
|
inflammatory response
|
|
| 8246 |
TLR2
|
|
affects_activity of
|
inflammatory response
|
|
|
17905482
|
Alzheimer disease
Amyotrophic lateral sclerosis
Parkinson disease
|
|
1,169
|
| 7760 |
IL1B
|
|
affects_activity of
|
inflammatory response
|
|
|
15290893
|
Alzheimer disease
Down syndrome
|
|
1,184
|
| 7845 |
microglial cell activation
|
|
increases_activity of
|
inflammatory response
|
within the diseased brain
|
| 7858 |
Amyloid beta peptide (fibrillar)
|
|
increases_activity of
|
inflammatory response
|
|
|
17094809
|
Alzheimer disease
Chronic granulomatous disease
|
|
1,206
|
| 8094 |
MT-CO1
|
|
increases_activity of
|
inflammatory response
|
in neurons
|
|
20409326
|
Parkinson disease
|
|
1,207
|
| 13379 |
recruited adipose tissue macrophage
|
|
increases_activity of
|
inflammatory response
|
|
|
17192460
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,215
|
| 8165 |
microglial cell activation
|
|
increases_activity of
|
inflammatory response
|
in brain
|
| 8189 |
PTGS2
|
|
increases_activity of
|
inflammatory response
|
|
| 8190 |
NOS2
|
|
increases_activity of
|
inflammatory response
|
|
|
17537546
|
Parkinson disease
|
|
1,217
|
| 8213 |
Estradiol
|
|
increases_activity of
|
inflammatory response
|
|
|
19164473
|
Diabetes mellitus, type II
Insulin resistance
|
|
1,218
|
| 8184 |
TNF
|
|
increases_activity of
|
inflammatory response
|
|
|
17537546
|
Parkinson disease
|
|
1,229
|
| 8257 |
HMOX1
|
|
decreases_activity of
|
inflammatory response
|
|
|
16467537
|
Parkinson disease
|
|
1,230
|
| 8266 |
HMOX1
|
|
decreases_activity of
|
inflammatory response
|
|
| 8267 |
astrocyte
|
|
decreases_activity of
|
inflammatory response
|
via induction of microglial HO-1
|
|
16467537
|
Parkinson disease
|
CIDeRplus